Title:
NUCLEOSIDE ANALOG AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/218274
Kind Code:
A1
Abstract:
The present invention relates to a nucleoside analog as shown in the following formula and a use thereof. Specifically, the present invention relates to a nucleoside analog as shown in the following formula, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof, and a use thereof in preparing (a) inhibitors for inhibiting the replication of coronaviruses, paramyxoviruses, influenza viruses, flaviviruses, filoviruses, Bunya viruses and/or arenaviruses; and/or (b) drugs for treating and/or preventing and mitigating diseases caused by coronaviruses, paramyxoviruses, influenza viruses, flaviviruses, filoviruses, Bunya viruses and/or arenaviruses.
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Inventors:
SHEN JINGSHAN (CN)
XIE YUANCHAO (CN)
HU TIANWEN (CN)
XIE YUANCHAO (CN)
HU TIANWEN (CN)
Application Number:
PCT/CN2022/086215
Publication Date:
October 20, 2022
Filing Date:
April 12, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07H19/24; A61K31/7048; A61K31/7068; A61K31/7076; A61P31/12; A61P31/14; A61P31/16
Domestic Patent References:
| WO2006033709A2 | 2006-03-30 | |||
| WO2019053696A1 | 2019-03-21 | |||
| WO2014209979A1 | 2014-12-31 | |||
| WO2012040124A1 | 2012-03-29 | |||
| WO2008071571A1 | 2008-06-19 | |||
| WO1989010361A1 | 1989-11-02 | |||
| WO2022038539A2 | 2022-02-24 | |||
| WO2022047065A2 | 2022-03-03 |
Foreign References:
| JPH0344397A | 1991-02-26 | |||
| FR1354426A | 1964-03-06 | |||
| CN113929724A | 2022-01-14 |
Other References:
CAPELLO, M. GONZALEZ, M. RODRIGUEZ, S.D. IGLESIAS, L.E. IRIBARREN, A.M.: "A mild and quantitative procedure for the removal of nucleoside alkoxycarbonyl groups using pig liver esterase or Candida antarctica B lipase", JOURNAL OF MOLECULAR CATALYSIS B : ENZYMATIC, vol. 36, no. 1-6, 1 November 2005 (2005-11-01), pages 36 - 39, XP005105112, ISSN: 1381-1177, DOI: 10.1016/j.molcatb.2005.08.001
HANESSIAN, S. HUYNH, H.K.: "Solution and Solid Phase p-Alkoxybenzylation of Alcohols under Neutral Conditions", TETRAHEDRON LETTERS, vol. 40, no. 4, 22 January 1999 (1999-01-22), Amsterdam , NL , pages 671 - 674, XP004151414, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(98)02531-3
DAVISSON V. JO, DAVIS DARRELL R., DIXIT VYAS M., POULTER C. DALE: "Synthesis of nucleotide 5'-diphosphates from 5'-O-tosyl nucleosides", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 52, no. 9, 1 May 1987 (1987-05-01), pages 1794 - 1801, XP055976668, ISSN: 0022-3263, DOI: 10.1021/jo00385a026
CRAMER P., BÄR H.P., RHAESE H.J., SÄNGER W., SCHEIT K.H., SCHNEIDER G., TENNIGKEIT J.: "Stability of protective groups for nucleosides and nucleotides", TETRAHEDRON LETTERS, no. 16, 1 January 1963 (1963-01-01), pages 1039 - 1042, XP055976673, ISBN: 978-1-4831-9886-6, DOI: 10.1016/B978-1-4831-9886-6.50210-2
MIKHAILOPULO I. A., KALINICHENKO E. N., ZAITSEVA G. V., AKHREM A. A.: "Mass spectrometry of some modified nucleosides of the pyrimidine and purine series", BIOMEDICAL MASS SPECTROMETRY, vol. 9, no. 6, 1 June 1982 (1982-06-01), GB , pages 225 - 232, XP055976676, ISSN: 0306-042X, DOI: 10.1002/bms.1200090602
CRAMER, FRIEDRICH; SAENGER, WOLFRAM; SCHEIT, KARL-HEINZ; TENNIGKEIT, JÜRGEN: "Über substituierte 2.3-Benzyliden-ribonucleoside = [Substituted 2, 3-benzylidene ribonucleosides]", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 679, no. 1, 31 December 1964 (1964-12-31), pages 156 - 163, XP009540354, DOI: 10.1002/jlac.19646790122
HANESSIAN, S. HUYNH, H.K.: "Solution and Solid Phase p-Alkoxybenzylation of Alcohols under Neutral Conditions", TETRAHEDRON LETTERS, vol. 40, no. 4, 22 January 1999 (1999-01-22), Amsterdam , NL , pages 671 - 674, XP004151414, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(98)02531-3
DAVISSON V. JO, DAVIS DARRELL R., DIXIT VYAS M., POULTER C. DALE: "Synthesis of nucleotide 5'-diphosphates from 5'-O-tosyl nucleosides", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 52, no. 9, 1 May 1987 (1987-05-01), pages 1794 - 1801, XP055976668, ISSN: 0022-3263, DOI: 10.1021/jo00385a026
CRAMER P., BÄR H.P., RHAESE H.J., SÄNGER W., SCHEIT K.H., SCHNEIDER G., TENNIGKEIT J.: "Stability of protective groups for nucleosides and nucleotides", TETRAHEDRON LETTERS, no. 16, 1 January 1963 (1963-01-01), pages 1039 - 1042, XP055976673, ISBN: 978-1-4831-9886-6, DOI: 10.1016/B978-1-4831-9886-6.50210-2
MIKHAILOPULO I. A., KALINICHENKO E. N., ZAITSEVA G. V., AKHREM A. A.: "Mass spectrometry of some modified nucleosides of the pyrimidine and purine series", BIOMEDICAL MASS SPECTROMETRY, vol. 9, no. 6, 1 June 1982 (1982-06-01), GB , pages 225 - 232, XP055976676, ISSN: 0306-042X, DOI: 10.1002/bms.1200090602
CRAMER, FRIEDRICH; SAENGER, WOLFRAM; SCHEIT, KARL-HEINZ; TENNIGKEIT, JÜRGEN: "Über substituierte 2.3-Benzyliden-ribonucleoside = [Substituted 2, 3-benzylidene ribonucleosides]", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 679, no. 1, 31 December 1964 (1964-12-31), pages 156 - 163, XP009540354, DOI: 10.1002/jlac.19646790122
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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