Title:
NUCLEOSIDE ANALOGUES
Document Type and Number:
WIPO Patent Application WO1990005736
Kind Code:
A3
Abstract:
The present invention relates to nucleoside phosphate triesters and processes for their preparation. In particular, the present invention relates to nucleoside analogues of formula (I), where B = an organic base, X = -H or -N3, Z = -NR<1>R<2>, and Y = -OR<3> or NR<4>R<5>, wherein R<1>, R<2>, R<3>, R<4> and R<5> are the same or different and are selected from -H, alkyl, aryl, acyl, substituted alkyl, substituted aryl and substituted acyl groups.
Inventors:
MCGUIGAN CHRISTOPHER (GB)
Application Number:
PCT/GB1989/001401
Publication Date:
July 12, 1990
Filing Date:
November 23, 1989
Export Citation:
Assignee:
MEDICAL RES COUNCIL (GB)
UNIV LONDON (GB)
UNIV LONDON (GB)
International Classes:
A61K31/66; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61P31/12; C07F9/655; C07H19/10; C07H19/16; C07H19/20; (IPC1-7): C07H19/00; A61K31/70; C07F9/26; C07H19/06; C07H19/10; C07H19/16; C07H19/20
Foreign References:
| US3280104A | 1966-10-18 | |||
| US3082203A | 1963-03-19 | |||
| US3534017A | 1970-10-13 | |||
| DE1595938A1 | 1970-07-09 | |||
| GB2181128A | 1987-04-15 | |||
| EP0206497A2 | 1986-12-30 |
Other References:
Patent Abstracts of Japan, Vol 7, No 252, C194, abstract of JP 58-140100, publ 1983-08-19
Patent Abstracts of Japan, Vol 6, No 223, C133, abstract of JP 57-128699, publ 1982-08-10
J. Med. Chem., Vol. 27, 1984 Ram R. Chawla et al.: "Bis(m-nitrophenyl) and Bis (p-nitrophenyl) Esters and the Phosphorodiamidate of Thymidine 5'-Phosphate as Potential Sources of Intracellular Thymidine 5'-Phosphate in Mouse Cells i",
J. Med. Chem., Vol. 26, 1983 David Farquhar et al.: "Synthesis and Biological Evaluation of Neutral Derivatives of 5-Fluoro-2'-deoxyuridine 5'-Phosphate ",
Patent Abstracts of Japan, Vol 6, No 223, C133, abstract of JP 57-128699, publ 1982-08-10
J. Med. Chem., Vol. 27, 1984 Ram R. Chawla et al.: "Bis(m-nitrophenyl) and Bis (p-nitrophenyl) Esters and the Phosphorodiamidate of Thymidine 5'-Phosphate as Potential Sources of Intracellular Thymidine 5'-Phosphate in Mouse Cells i",
J. Med. Chem., Vol. 26, 1983 David Farquhar et al.: "Synthesis and Biological Evaluation of Neutral Derivatives of 5-Fluoro-2'-deoxyuridine 5'-Phosphate ",
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