Title:
NUCLEOSIDE ARYL PHOSPHORAMIDATES AND THEIR USE AS ANTI-VIRAL AGENTS FOR THE TREATMENT OF HEPATITIS C VIRUS
Document Type and Number:
WIPO Patent Application WO/2008/062206
Kind Code:
A8
Abstract:
Phosphoramidate derivatives of nucleoside compounds of formula I derived from bases such as adenine and guanine have enhanced therapeutic potency, in particular, enhanced potency with respect to the prophylaxis or treatment of a viral infection such as hepatitis C virus. The glycoside moiety of the nucleoside compound is suitably substituted at the β-2' position with methyl and the phosphoramidate group, suitably comprises 1-naphthyl linked by -O- to the P atom.
Inventors:
MCGUIGAN CHRISTOPHER (GB)
NEYTS JOHAN (BE)
PERRONE PLINIO (IT)
NEYTS JOHAN (BE)
PERRONE PLINIO (IT)
Application Number:
PCT/GB2007/004480
Publication Date:
November 10, 2011
Filing Date:
November 23, 2007
Export Citation:
Assignee:
UNIV CARDIFF (GB)
UNIV LEUVEN KATH (BE)
MCGUIGAN CHRISTOPHER (GB)
NEYTS JOHAN (BE)
PERRONE PLINIO (IT)
UNIV LEUVEN KATH (BE)
MCGUIGAN CHRISTOPHER (GB)
NEYTS JOHAN (BE)
PERRONE PLINIO (IT)
International Classes:
C07H19/20; A61K31/7076; A61K31/708; A61P31/14
Attorney, Agent or Firm:
CRUMP, Julian, Richard, John (Cohn Ferris, Lovsky and Popeo,Inttellectual Property, LLP,Alder Castle, London EC2V 7JX, GB)
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