Title:
NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE
Document Type and Number:
WIPO Patent Application WO2004000858
Kind Code:
A3
Abstract:
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.
Inventors:
CARROLL STEVEN S (US)
OLSEN DAVID B (US)
DURETTE PHILIPPE L (US)
BHAT BALKRISHEN (US)
DANDE PRASAD (US)
ELDRUP ANNE B (US)
OLSEN DAVID B (US)
DURETTE PHILIPPE L (US)
BHAT BALKRISHEN (US)
DANDE PRASAD (US)
ELDRUP ANNE B (US)
Application Number:
PCT/US2003/019172
Publication Date:
May 12, 2005
Filing Date:
June 17, 2003
Export Citation:
Assignee:
MERCK & CO INC (US)
ISIS PHARMACEUTICALS INC (US)
CARROLL STEVEN S (US)
OLSEN DAVID B (US)
DURETTE PHILIPPE L (US)
BHAT BALKRISHEN (US)
DANDE PRASAD (US)
ELDRUP ANNE B (US)
ISIS PHARMACEUTICALS INC (US)
CARROLL STEVEN S (US)
OLSEN DAVID B (US)
DURETTE PHILIPPE L (US)
BHAT BALKRISHEN (US)
DANDE PRASAD (US)
ELDRUP ANNE B (US)
International Classes:
A61K31/7056; A61K31/7068; A61K31/7072; A61K31/7076; A61K38/21; C07H19/067; A61K45/00; A61P31/14; A61P43/00; C07H19/06; C07H19/10; C07H19/16; C07H19/167; C07H19/20; (IPC1-7): A61K31/70; C07H19/06; C07H19/10; C07H19/167; C07H19/20
Domestic Patent References:
| WO2002057287A2 | 2002-07-25 | |||
| WO2002057425A2 | 2002-07-25 | |||
| WO2001016379A1 | 2001-03-08 |
Other References:
DATABASE HCAPLUS [online] XP002985894, accession no. STN Database accession no. 2003:892793
LI ET AL: "2'-C-Branched Ribonucleotides.2.Synthesis of 2'-C-beta-Trifluoromethyl Pyrimidine Ribonucleosides", ORGANIC LETTERS, vol. 3, no. 7, 8 March 2001 (2001-03-08), pages 1025 - 1028, XP002287440
DUNKEL ET AL: "Synthesis of 2'-C-Difluormethyl Substituted Nucleoside Analogs as Ribonucleoside Replacements in Hammerhead Ribozymes", NUCLEOSIDES & NUCLEOTIDES, vol. 14, no. 3-5, 1995, pages 799 - 801, XP009014832
LI ET AL: "2'-C-Branched Ribonucleotides.2.Synthesis of 2'-C-beta-Trifluoromethyl Pyrimidine Ribonucleosides", ORGANIC LETTERS, vol. 3, no. 7, 8 March 2001 (2001-03-08), pages 1025 - 1028, XP002287440
DUNKEL ET AL: "Synthesis of 2'-C-Difluormethyl Substituted Nucleoside Analogs as Ribonucleoside Replacements in Hammerhead Ribozymes", NUCLEOSIDES & NUCLEOTIDES, vol. 14, no. 3-5, 1995, pages 799 - 801, XP009014832
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