Title:
NUCLEOSIDE AND NUCLEOTIDE HAVING SULFONAMIDE STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2014/112463
Kind Code:
A1
Abstract:
The invention provides compounds shown by the formula (in the formula Y1-Y2 is S(=O)2-NR6, NR6-S(=O)2, or the like; R6 is a hydrogen atom, substituted or unsubstituted alkyl group, or the like; Bx is a nucleic acid base moiety; Z1 and Z2 are each independently a hydrogen atom, hydroxyl group protecting group, or reactive phosphorus group; R1-R5 are each independently a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl group, or the like; and n is an integer of 0-3), or salts thereof, that are novel nucleosides or nucleotides that can be utilized as materials for synthesizing nucleic acid pharmaceuticals.
Inventors:
OBIKA SATOSHI (JP)
MITSUOKA YASUNORI (JP)
MITSUOKA YASUNORI (JP)
Application Number:
PCT/JP2014/050429
Publication Date:
July 24, 2014
Filing Date:
January 14, 2014
Export Citation:
Assignee:
UNIV OSAKA (JP)
SHIONOGI & CO (JP)
SHIONOGI & CO (JP)
International Classes:
C07H19/067; C07H19/10; C07H19/167; C07H19/20; C07H21/04
Domestic Patent References:
| WO2011052436A1 | 2011-05-05 | |||
| WO2011010706A1 | 2011-01-27 | |||
| WO2010150789A1 | 2010-12-29 | |||
| WO2010113937A1 | 2010-10-07 | |||
| WO2010021344A1 | 2010-02-25 | |||
| WO2005021570A1 | 2005-03-10 |
Foreign References:
| JP2009524695A | 2009-07-02 |
Other References:
MORI, KAZUTO; ET AL.: "Bridged nucleic acid conjugates at 6'-thiol: synthesis, hybridization properties and nuclease resistances", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, no. 14, 2011, pages 5272 - 5279
BABA, TAKESHI; ET AL.: "A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes", CHEMICAL COMMUNICATIONS, vol. 46, no. 42, 2010, pages 8058 - 8060
BABA, TAKESHI; ET AL.: "Synthesis and properties of a novel artificial nucleoside that acts as a redox switch", NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 53, no. 1, 2009, pages 107 - 108
VAN NHIEN ET AL.: "First Synthesis and Evaluation of the Inhibitory Effects of Aza Analogues of TSAO on HIV-1 Replication", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 13, 2005, pages 4276 - 4284
BABA, TAKESHI; ET AL.: "A novel bridged nucleoside bearing a conformationally switchable sugar moiety in response to redox changes", CHEMICAL COMMUNICATIONS, vol. 46, no. 42, 2010, pages 8058 - 8060
BABA, TAKESHI; ET AL.: "Synthesis and properties of a novel artificial nucleoside that acts as a redox switch", NUCLEIC ACIDS SYMPOSIUM SERIES, vol. 53, no. 1, 2009, pages 107 - 108
VAN NHIEN ET AL.: "First Synthesis and Evaluation of the Inhibitory Effects of Aza Analogues of TSAO on HIV-1 Replication", JOURNAL OF MEDICINAL CHEMISTRY, vol. 48, no. 13, 2005, pages 4276 - 4284
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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