Title:
NUCLIDE-LABELED INHIBITORY PEPTIDE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/226530
Kind Code:
A1
Abstract:
A nuclide-labeled inhibitory peptide, a preparation method therefor and the use thereof. An ASF1a peptide is labeled with 68Ga/177Lu by DOTA; and the amino acid sequence of the ASF1A peptide is YGRKKRRQRRRCASTEEKWARLARRIAGAGGVTLDGFGGCA. By means of the 68Ga-labeled ASF1a inhibitory peptide, the expression level of ASF1a in tumors is displayed by PET/CT imaging, and the imaging sensitivity is good, high-expression and low-expression individuals can be specifically screened, and the non-invasive prediction of the therapeutic effect of tumor immunotherapy is realized. The 177Lu-labeled ASF1a inhibitory peptide provides a new effective treatment strategy for tumors which highly express ASF1a and are ineffective in immunotherapy.
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Inventors:
YANG KAI (CN)
SHI XIUMIN (CN)
SHI XIUMIN (CN)
Application Number:
PCT/CN2023/081067
Publication Date:
November 30, 2023
Filing Date:
March 13, 2023
Export Citation:
Assignee:
UNIV SUZHOU (CN)
International Classes:
C07K14/47; A61K51/08; A61P35/00; A61P35/04; C07K1/13; C07K1/16
Domestic Patent References:
| WO2021238842A1 | 2021-12-02 | |||
| WO2022021528A1 | 2022-02-03 |
Foreign References:
| CN114874308A | 2022-08-09 | |||
| CN104491890A | 2015-04-08 | |||
| CN107021998A | 2017-08-08 | |||
| US20150025016A1 | 2015-01-22 | |||
| US20150132219A1 | 2015-05-14 |
Other References:
JIANG LI-SHA; WANG XIN-LU; YIN JI-LIN; WANG CHENG;: "68ga Labeled Somatostatin Analogues for Tumor Imaging", JOURNAL OF CHINA CLINIC MEDICAL IMAGING, vol. 26, no. 05, 20 May 2015 (2015-05-20), pages 365 - 368, XP009550619, ISSN: 1008-1062
Attorney, Agent or Firm:
RZBC PATENT AGENCY (GENERAL PARTNERSHIP) (CN)
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