Title:
NUTRITIONAL COMPOSITION FOR PREVENTING BRONCHITIS
Document Type and Number:
WIPO Patent Application WO/2024/005043
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel nutritional composition by finding ingredients for preventing the onset of bronchitis from breast milk ingredients. The present invention relates to a nutritional composition for preventing the onset of bronchitis, said nutritional composition being characterized by containing, as active ingredients, N-acetylneuraminic acid, 6'-sialyllactose, an α2,6 disialo N-linked sugar chain and a disialo N-linked sugar chain of a specific structure. This nutritional composition provides the effective ingredients not only for infants but also for aged persons and those having a pre-existing disease at high risk of bronchitis and, therefore, is also efficacious as a nutritional composition that is used in foods and nutritional compositions for adults and aged persons for preventing the onset of bronchitis.
Inventors:
YAMAGUCHI TOSHIYUKI (JP)
HIGUCHI JUNICHI (JP)
FUKUDOME HIROFUMI (JP)
SAKAI FUMIHIKO (JP)
TSUJIMORI YUTA (JP)
TAKAHASHI TOMOKI (JP)
HIGUCHI JUNICHI (JP)
FUKUDOME HIROFUMI (JP)
SAKAI FUMIHIKO (JP)
TSUJIMORI YUTA (JP)
TAKAHASHI TOMOKI (JP)
Application Number:
PCT/JP2023/023898
Publication Date:
January 04, 2024
Filing Date:
June 28, 2023
Export Citation:
Assignee:
MEGMILK SNOW BRAND CO LTD (JP)
International Classes:
A23L33/10; A23C9/152; A23L2/38; A23L2/52; A23L33/125; A61K31/7008; A61K31/702; A61K31/715; A61K47/54; A61K47/64; A61P11/00
Domestic Patent References:
| WO2020246585A1 | 2020-12-10 | |||
| WO1996002255A1 | 1996-02-01 |
Foreign References:
| US20130236424A1 | 2013-09-12 | |||
| JP2013231012A | 2013-11-14 |
Other References:
MIYATA T., ET AL.: "EFFECT OF N-ACETYLNEURAMINIC ACID ON RESPIRATORY TRACT SECRETION AND INFLAMMATION IN THE BRONCHITIC RABBIT.", ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE, vol. 304., 1 January 1990 (1990-01-01), pages 277 - 289., XP000943397, ISSN: 0003-9780
ISHII I., NISHI N., MATSUMOTO N., ODA Y., MURATA Y., OGASAWARA S., OKANO Y., TAKAHAMA K., KAI H., MIYATA T.: "Possible contribution of N-acetylneuraminic acid (NANA) in the airway defense system", THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 46, no. suppl.1, 1 January 1988 (1988-01-01), pages 284, XP093122952, DOI: 10.1016/S0021-5198(19)57693-4
ANONYMOUS: "Breastfeeding and the Use of Human Milk", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, US, vol. 129, no. 3, 1 March 2012 (2012-03-01), US , pages e827 - e841, XP055654909, ISSN: 0031-4005, DOI: 10.1542/peds.2011-3552
LANARI MARCELLO, PRINELLI FEDERICA, ADORNI FULVIO, DI SANTO SIMONA, FALDELLA GIACOMO, SILVESTRI MICHELA, MUSICCO MASSIMO: "Maternal milk protects infants against bronchiolitis during the first year of life. Results from an Italian cohort of newborns", EARLY HUMAN DEVELOPMENT, SHANNON, IR, vol. 89, 1 June 2013 (2013-06-01), IR , pages S51 - S57, XP093122956, ISSN: 0378-3782, DOI: 10.1016/S0378-3782(13)70016-1
DIXON DANI-LOUISE: "The Role of Human Milk Immunomodulators in Protecting Against Viral Bronchiolitis and Development of Chronic Wheezing Illness", CHILDREN, MDPI AG, vol. 2, no. 3, 7 July 2015 (2015-07-07), pages 289 - 304, XP055922800, DOI: 10.3390/children2030289
PIERCE-CRETEL ANNICK, PAMBLANCO MERCEDES, STRECKER GERARD, MONTREUIL JEAN, SPIK GENEVIEVE, DORLAND LAMBERTUS, HALBEEK HERMAN, VLIE: "Primary Structure of the N-Glycosidically Linked Sialoglycans of Secretory Immunoglobulins A from Human Milk", EUROPEAN JOURNAL OF BIOCHEMISTRY, PUBLISHED BY SPRINGER-VERLAG ON BEHALF OF THE FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETIES, HOBOKEN, USA, vol. 125, no. 2, 1 July 1982 (1982-07-01), Hoboken, USA, pages 383 - 388, XP093122958, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1982.tb06694.x
YU YING, MISHRA SHREYA, SONG XUEZHENG, LASANAJAK YI, BRADLEY KONRAD C., TAPPERT MARY M., AIR GILLIAN M., STEINHAUER DAVID A., HALD: "Functional Glycomic Analysis of Human Milk Glycans Reveals the Presence of Virus Receptors and Embryonic Stem Cell Biomarkers", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 287, no. 53, 1 December 2012 (2012-12-01), US , pages 44784 - 44799, XP093122961, ISSN: 0021-9258, DOI: 10.1074/jbc.M112.425819
ISHII I., NISHI N., MATSUMOTO N., ODA Y., MURATA Y., OGASAWARA S., OKANO Y., TAKAHAMA K., KAI H., MIYATA T.: "Possible contribution of N-acetylneuraminic acid (NANA) in the airway defense system", THE JAPANESE JOURNAL OF PHARMACOLOGY, vol. 46, no. suppl.1, 1 January 1988 (1988-01-01), pages 284, XP093122952, DOI: 10.1016/S0021-5198(19)57693-4
ANONYMOUS: "Breastfeeding and the Use of Human Milk", PEDIATRICS, AMERICAN ACADEMY OF PEDIATRICS, US, vol. 129, no. 3, 1 March 2012 (2012-03-01), US , pages e827 - e841, XP055654909, ISSN: 0031-4005, DOI: 10.1542/peds.2011-3552
LANARI MARCELLO, PRINELLI FEDERICA, ADORNI FULVIO, DI SANTO SIMONA, FALDELLA GIACOMO, SILVESTRI MICHELA, MUSICCO MASSIMO: "Maternal milk protects infants against bronchiolitis during the first year of life. Results from an Italian cohort of newborns", EARLY HUMAN DEVELOPMENT, SHANNON, IR, vol. 89, 1 June 2013 (2013-06-01), IR , pages S51 - S57, XP093122956, ISSN: 0378-3782, DOI: 10.1016/S0378-3782(13)70016-1
DIXON DANI-LOUISE: "The Role of Human Milk Immunomodulators in Protecting Against Viral Bronchiolitis and Development of Chronic Wheezing Illness", CHILDREN, MDPI AG, vol. 2, no. 3, 7 July 2015 (2015-07-07), pages 289 - 304, XP055922800, DOI: 10.3390/children2030289
PIERCE-CRETEL ANNICK, PAMBLANCO MERCEDES, STRECKER GERARD, MONTREUIL JEAN, SPIK GENEVIEVE, DORLAND LAMBERTUS, HALBEEK HERMAN, VLIE: "Primary Structure of the N-Glycosidically Linked Sialoglycans of Secretory Immunoglobulins A from Human Milk", EUROPEAN JOURNAL OF BIOCHEMISTRY, PUBLISHED BY SPRINGER-VERLAG ON BEHALF OF THE FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETIES, HOBOKEN, USA, vol. 125, no. 2, 1 July 1982 (1982-07-01), Hoboken, USA, pages 383 - 388, XP093122958, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1982.tb06694.x
YU YING, MISHRA SHREYA, SONG XUEZHENG, LASANAJAK YI, BRADLEY KONRAD C., TAPPERT MARY M., AIR GILLIAN M., STEINHAUER DAVID A., HALD: "Functional Glycomic Analysis of Human Milk Glycans Reveals the Presence of Virus Receptors and Embryonic Stem Cell Biomarkers", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 287, no. 53, 1 December 2012 (2012-12-01), US , pages 44784 - 44799, XP093122961, ISSN: 0021-9258, DOI: 10.1074/jbc.M112.425819
Attorney, Agent or Firm:
MOEGI PATENT ATTORNEYS (JP)
Download PDF: