Title:
O-SUBSTITUTED HYDROXYARYL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2003/103656
Kind Code:
A1
Abstract:
Drugs having inhibitory activity against NF-κB activation, containing as the active ingredient substances selected from the group consisting of compounds represented by the general formula (I), pharmacologically acceptable salts thereof, and hydrates and solvates of both: (I) wherein X is a connecting group whose main chain has two to five atoms and which may be substituted; A is optionally substituted acyl (exclusive of unsubstituted acetyl and unsubstituted acryloyl) or optionally substituted C1-6 alkyl, or alternatively A and X may be united to form a ring structure which may be substituted; E is optionally substituted aryl or optionally substituted heteroaryl; and Z is arene which may have a substituent in addition to the groups represented by the general formulae: -O-A (wherein A is as defined above) and -X-E (wherein X and E are each as defined above) or heteroarene which may have a substituent in addition to the groups represented by the general formulae: -O-A (wherein A is as defined above) and -X-E (wherein X and E are each as defined above).
Inventors:
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
ITAI AKIKO (JP)
Application Number:
PCT/JP2003/007127
Publication Date:
December 18, 2003
Filing Date:
June 05, 2003
Export Citation:
Assignee:
INST MED MOLECULAR DESIGN INC (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
MUTO SUSUMU (JP)
ITAI AKIKO (JP)
International Classes:
A61P29/00; A61P37/06; A61P43/00; C07D209/48; C07D211/62; C07D213/803; C07D265/22; C07D265/26; C07D269/00; C07D273/00; C07D277/46; C07D295/185; C07D295/205; C07D309/10; C07D317/60; C07K5/06; C07K5/065; C07K5/068; C07K5/072; C07D213/79; (IPC1-7): A61K31/167; A61K31/18; A61K31/222; A61K31/27; A61K31/4035; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4453; A61K31/495; A61K31/536; A61K31/5377; A61K31/55; A61K31/609; A61K31/625; A61K31/661; A61K31/7034; A61K38/00; A61P29/00; A61P37/06; A61P43/00; C07D209/48; C07D211/62; C07D265/22; C07D265/26; C07D267/00; C07D277/46; C07D295/18; C07D295/20; C07D317/68
Domestic Patent References:
| WO2001012588A1 | 2001-02-22 | |||
| WO2002049632A1 | 2002-06-27 | |||
| WO2002076918A1 | 2002-10-03 | |||
| WO1999065449A2 | 1999-12-23 | |||
| WO2001000213A1 | 2001-01-04 | |||
| WO2001044217A1 | 2001-06-21 |
Foreign References:
| JP2000169479A | 2000-06-20 | |||
| JPS52110835A | 1977-09-17 | |||
| GB2031410A | 1980-04-23 | |||
| US3906023A | 1975-09-16 | |||
| FR1481713A | 1967-05-19 |
Other References:
HSI RICHARD S.P. ET AL.: "Hydrolysis of salicylanilide carbamates", JOURNAL OF ORGANIC CHEMISTRY, vol. 37, no. 22, 1972, pages 3427 - 3431, XP002972324
KLOSA J.: "Synthesis of amides from alkoxybenzoic acids and 4-amino-1-phenyl-2,3-dimethyl-5-pyrazolone", JOURNAL FUER PRAKTISCHE CHEMIE, vol. 25, no. 1-2, 1964, LEIPZIG, pages 48 - 55, XP002972325
WEST S, ET AL.: "A multiple-staining procedure for the detection of different DNA fragments on a single blot", ANALYTICAL BIOCHEMISTRY, vol. 190, no. 2, 1990, pages 254 - 258, XP002972326
KLOSA J.: "Synthesis of amides from alkoxybenzoic acids and 4-amino-1-phenyl-2,3-dimethyl-5-pyrazolone", JOURNAL FUER PRAKTISCHE CHEMIE, vol. 25, no. 1-2, 1964, LEIPZIG, pages 48 - 55, XP002972325
WEST S, ET AL.: "A multiple-staining procedure for the detection of different DNA fragments on a single blot", ANALYTICAL BIOCHEMISTRY, vol. 190, no. 2, 1990, pages 254 - 258, XP002972326
Attorney, Agent or Firm:
SIKS & CO. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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