Title:
OPIATE ANALOGS SELECTIVE FOR THE delta-OPIOID RECEPTOR
Document Type and Number:
WIPO Patent Application WO2004026819
Kind Code:
A3
Abstract:
Novel compounds which selectively bind to the delta-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the delta-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known µ-opioid receptor selectors as analgesics.
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Inventors:
WELSH WILLIAM J (US)
YU SEONG JAE (US)
NAIR ANIL (US)
YU SEONG JAE (US)
NAIR ANIL (US)
Application Number:
PCT/US2003/029455
Publication Date:
July 01, 2004
Filing Date:
September 18, 2003
Export Citation:
Assignee:
UNIV MISSOURI (US)
WELSH WILLIAM J (US)
YU SEONG JAE (US)
NAIR ANIL (US)
WELSH WILLIAM J (US)
YU SEONG JAE (US)
NAIR ANIL (US)
International Classes:
A61P25/04; C07D471/10; C07D471/22; C07D489/08; C07D491/20; C07D491/22; C07D498/08; (IPC1-7): C07D489/08; A61K31/485; A61P25/04; C07D489/09
Foreign References:
| US5578725A | 1996-11-26 | |||
| US5852030A | 1998-12-22 |
Other References:
See also references of EP 1539767A4
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