Title:
ORGANS FOR TRANSPLANTATION INDUCED $i(IN VITRO)
Document Type and Number:
WIPO Patent Application WO/2000/044881
Kind Code:
A1
Abstract:
Organs for transplantation aiming at establishing a method for the induction $i(in vitro) and vital transplantation of organs with the use of embryological or organological techniques so as to evaluate whether or not organs induced $i(in vitro) actually function $i(in vivo), and opening the way for the transplantation therapy for higher animals suffering from congenital renal diseases, etc. In the presence of a member of the TGF-$g(b) family such as activin, an organ (kidney, heart, pancreas, intestinal tract, etc.) having been induced $i(in vitro) is cultured until a definite developmental stage appropriate for the developmental stage of a recipient animal of the same species to thereby provide an organ which can function $i(in vivo) after transplantation. The developmental stage can be examined by using as a molecular marker a genomic DNA which is expressed depending on the developmental stage of the organ having been induced $i(in vitro).
Inventors:
ASASHIMA MAKOTO (JP)
ARIIZUMI TAKASHI (JP)
CHAN TE-CHUAN (JP)
ARIIZUMI TAKASHI (JP)
CHAN TE-CHUAN (JP)
Application Number:
PCT/JP2000/000148
Publication Date:
August 03, 2000
Filing Date:
January 14, 2000
Export Citation:
Assignee:
JAPAN SCIENCE & TECH CORP (JP)
ASASHIMA MAKOTO (JP)
ARIIZUMI TAKASHI (JP)
CHAN TE CHUAN (JP)
ASASHIMA MAKOTO (JP)
ARIIZUMI TAKASHI (JP)
CHAN TE CHUAN (JP)
International Classes:
A01K67/027; C12N5/07; C12N5/071; C12N5/077; C12N5/078; C12Q1/68; A61K35/12; (IPC1-7): C12N5/06
Foreign References:
| JPH03147782A | 1991-06-24 | |||
| JPH06277050A | 1994-10-04 |
Other References:
NAOMI MORIYA, ET. AL.: "Formation and Transplantation of Artificial Organ using the Early Embryo of Amphibia induced in Vitro (in Japanese)", BIO INDUSTRY, vol. 16, no. 6, 1999, pages 12 - 19, XP002930210
DATABASE MEDLINE CHAN T. C. ET. AL.: "A model system for organ engineering transplatation of in vitro induced embryonic kidney"
TAKEDO KOUZUKI ET. AL.: "Creating Pancreas Cells beta and Hepatocytes having Specific Function; An Approach to Hybrid Type Aritificial Organ (in Japanese)", PATHOPHYSIOLOGY (BYOTAI SEIRI), vol. 9, no. 11, 1990, pages 925 - 927, XP002930211
See also references of EP 1146118A4
DATABASE MEDLINE CHAN T. C. ET. AL.: "A model system for organ engineering transplatation of in vitro induced embryonic kidney"
TAKEDO KOUZUKI ET. AL.: "Creating Pancreas Cells beta and Hepatocytes having Specific Function; An Approach to Hybrid Type Aritificial Organ (in Japanese)", PATHOPHYSIOLOGY (BYOTAI SEIRI), vol. 9, no. 11, 1990, pages 925 - 927, XP002930211
See also references of EP 1146118A4
Attorney, Agent or Firm:
Hirota, Masanori (8-11 Akasaka 2-chom, Minato-ku Tokyo, JP)
Download PDF: