Title:
OBTAINING TANDEM MASS SPECTROMETRY DATA FOR MULTIPLE PARENT IONS IN AN ION POPULATION
Document Type and Number:
WIPO Patent Application WO2004083805
Kind Code:
A3
Abstract:
This invention relates to tandem mass spectrometry and, in particular, to tandem mass spectrometry using a linear ion trap and a time of flight detector to collect mass spectra to form a MS/MS experiment. The accepted standard is to store and mass analyze precursor ions in the ion trap before ejecting the ions axially to a collision cell for fragmentation before mass analysis of the fragments in the time of flight detector. This invention makes use of orthogonal ejection of ions with a narrow range of m/z values to produce a ribbon beam of ions that are injected into the collision cell. The shape of this beam and the high energy of the ions are accommodated by using a planar design of collision cell. Ions are retained in the ion trap during ejection so that successive narrow ranges may be stepped through consecutively to cover all precursor ions of interest.
Inventors:
MAKAROV ALEXANDER ALEKSEEVICH (GB)
SYKA JOHN EDWARD PHILIP (US)
SYKA JOHN EDWARD PHILIP (US)
Application Number:
PCT/GB2004/001174
Publication Date:
February 23, 2006
Filing Date:
March 19, 2004
Export Citation:
Assignee:
THERMO FINNIGAN LLC (US)
MAKAROV ALEXANDER ALEKSEEVICH (GB)
SYKA JOHN EDWARD PHILIP (US)
MAKAROV ALEXANDER ALEKSEEVICH (GB)
SYKA JOHN EDWARD PHILIP (US)
International Classes:
H01J49/40; H01J49/00; H01J49/42
Domestic Patent References:
| WO2001078106A2 | 2001-10-18 | |||
| WO2001015201A2 | 2001-03-01 |
Foreign References:
| US5763878A | 1998-06-09 | |||
| US20020092980A1 | 2002-07-18 | |||
| US5420425A | 1995-05-30 | |||
| US5783824A | 1998-07-21 | |||
| US5073713A | 1991-12-17 |
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