Title:
OCULAR-TENSION-INCREASING AGENT CAPABLE OF BEING DEPRIVED OF DRUG ACTIVITY BY TEMPERATURE CONTROL
Document Type and Number:
WIPO Patent Application WO/2022/092209
Kind Code:
A1
Abstract:
The present invention provides an ocular-tension-increasing agent containing a temperature-responsive polymer. By administering said ocular-tension-increasing agent to a specific region of an eye, the ocular tension thereof can be increased, and the ocular tension can be controlled with temperature according to need.
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Inventors:
TANAKA YUJI (JP)
KASHIWAGI KENJI (JP)
OSAWA SHIGEHITO (JP)
KASHIWAGI KENJI (JP)
OSAWA SHIGEHITO (JP)
Application Number:
PCT/JP2021/039837
Publication Date:
May 05, 2022
Filing Date:
October 28, 2021
Export Citation:
Assignee:
UNIV YAMANASHI (JP)
UNIV TOKYO SCIENCE FOUND (JP)
UNIV TOKYO SCIENCE FOUND (JP)
International Classes:
A61K31/74; A61P27/02
Foreign References:
| US20030223957A1 | 2003-12-04 |
Other References:
HWANG YIH-SHIOU, PING-RAY CHIANG, WEI-HSIN HONG, CHUAN-CHIN CHIAO, I-MING CHU, GINGHO HSIUE, CHIA-RUI SHEN: "Study In Vivo Intraocular Biocompatibility of In Situ Gelation Hydrogels: Poly(2-Ethyl Oxazoline)-Block-Poly(ε-Caprolactone)-Block-Poly(2-Ethyl Oxazoline) Copolymer, Matrigel and Pluronic F127", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, vol. 8, no. 7, 1 July 2013 (2013-07-01), US , pages e67495, XP055925708, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0067495
WEBER CHRISTINE, HOOGENBOOM RICHARD, SCHUBERT ULRICH S.: "Temperature responsive bio-compatible polymers based on poly(ethylene oxide) and poly(2-oxazoline)s", PROGRESS IN POLYMER SCIENCE, PERGAMON PRESS, OXFORD., GB, vol. 37, no. 5, 1 May 2012 (2012-05-01), GB , pages 686 - 714, XP055925711, ISSN: 0079-6700, DOI: 10.1016/j.progpolymsci.2011.10.002
WEBER CHRISTINE, HOOGENBOOM RICHARD, SCHUBERT ULRICH S.: "Temperature responsive bio-compatible polymers based on poly(ethylene oxide) and poly(2-oxazoline)s", PROGRESS IN POLYMER SCIENCE, PERGAMON PRESS, OXFORD., GB, vol. 37, no. 5, 1 May 2012 (2012-05-01), GB , pages 686 - 714, XP055925711, ISSN: 0079-6700, DOI: 10.1016/j.progpolymsci.2011.10.002
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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