OFF-TARGET RISK ANALYSIS METHOD, OFF-TARGET RISK ANALYSIS SYSTEM, PROGRAM AND RECORDING MEDIUM

WIPO Patent Application WO/2024/070589

A1

The present invention addresses the problem of predicting a potential off-target risk of a DNA-binding tool even when genomic information is unknown or indeterminate. An off-target risk analysis method that comprises: a virtual sequence generation step (S2) for generating a plurality of virtual sequences including a sequence identical to a target sequence and a sequence in which at least one mutation is introduced into the target sequence; a score calculation step (S3) for calculating a score relating to the probability that a DNA-binding tool recognizing the target sequence acts on for each of the plurality of the virtual sequences; and a predicted result output step (S4) for outputting, on the basis of the calculated score, the predicted result indicating the potentiality that the DNA-binding tool acts on a sequence different from the target sequence.

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SAKUMA TETSUSHI (JP)
NAKAMAE KAZUKI (JP)

PCT/JP2023/032841

April 04, 2024

September 08, 2023

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UNIV HIROSHIMA (JP)
PTBIO INC (JP)

G16B30/00

WO2021100731A1

2021-05-27

TAMANO, SHIYU: "Proposal of Evaluation Off-target Effects Method in Gapmer ASO", IPSJ SIG TECHNICAL REPORT, vol. 2022-BIO-69, no. 7, 10 March 2022 (2022-03-10), pages 1 - 7, XP009554159, ISSN: 2188-8590
TAKASHI YAMAMOTO: ""CRISPRdirect" Utilizing Genome Editing Technology: Designing Guide RNA with Little Off-Target Action", 23 November 2021 (2021-11-23), XP093152028, Retrieved from the Internet

HARAKENZO WORLD PATENT & TRADEMARK (JP)

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