Title:
3α-OLEANOLIC ACID DERIVATIVES AS HYALURONIDASE INHIBITORS AND USES THEREOF IN COSMETIC PRODUCTS
Document Type and Number:
WIPO Patent Application WO/2023/151292
Kind Code:
A1
Abstract:
The present invention relates to 3α-triazole-oleanolic acid derivatives, a preparation method therefor, and the uses of said derivatives serving as hyaluronidase inhibitors and used for preparing anti-aging cosmetic products. Specifically, disclosed in the present invention are 3α-triazole-oleanolic acid derivatives having structures shown as general formula (I), and a preparation method therefor. In vitro activity tests show that the oleanolic acid derivatives have strong hyaluronidase inhibition activity and IC50 being about 1-10 μg/mL, and the inhibitory activity is obviously stronger than that of oleanolic acid having IC50 being about 56 μg/mL. Cell proliferation experiments show that the 3α-triazole-oleanolic acid derivatives have very low mammalian cell cytotoxicity. The 3α-triazole-oleanolic acid derivatives have good lipid solubility, are easily absorbed by skin tissues, and may be used as an anti-aging component for preparing cosmetic products. Further disclosed in the present invention are the uses of the 3α-triazole-oleanolic acid derivatives as a cosmetic component to prepare anti-skin aging facial masks.
Inventors:
JIANG YANFEI (CN)
Application Number:
PCT/CN2022/123991
Publication Date:
August 17, 2023
Filing Date:
October 09, 2022
Export Citation:
Assignee:
BEIJING QINGYAN BOSHI HEALTH MAN CO LTD (CN)
International Classes:
C07J63/00; A61K8/63; A61K8/67; A61K8/73; A61Q19/08
Foreign References:
| CN114456225A | 2022-05-10 | |||
| CN102344481A | 2012-02-08 | |||
| CN106366151A | 2017-02-01 | |||
| CN106967146A | 2017-07-21 |
Other References:
DAS JAYANTA, SARKAR ANTARA, GHOSH PRANAB: "Friedelane triterpenoids: transformations toward A-ring modifications including 2- homo derivatives", NEW JOURNAL OF CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, vol. 42, no. 9, 1 January 2018 (2018-01-01), GB , pages 6673 - 6688, XP093083717, ISSN: 1144-0546, DOI: 10.1039/C8NJ00009C
Attorney, Agent or Firm:
BEIJING CEMO LEADER INTELLECTUAL PROPERTY AGENCY (CN)
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