Title:
OLIGONUCLEOTIDES FOR DGAT2 MODULATION
Document Type and Number:
WIPO Patent Application WO/2022/109398
Kind Code:
A9
Abstract:
This disclosure relates to novel DGAT2 targeting sequences. Novel DGAT2 targeting oligonucleotides for the treatment of non-alcoholic fatty liver disease (NAFLD) and lipodystrophy syndromes (or metabolic syndrome) are also provided.
Inventors:
CZECH MICHAEL P (US)
YENILMEZ BATUHAN ORBAY (US)
KHVOROVA ANASTASIA (US)
YENILMEZ BATUHAN ORBAY (US)
KHVOROVA ANASTASIA (US)
Application Number:
PCT/US2021/060356
Publication Date:
September 29, 2022
Filing Date:
November 22, 2021
Export Citation:
Assignee:
UNIV MASSACHUSETTS (US)
International Classes:
A61K31/7088; A61K31/713; C12N15/09; C12N15/11; C12N15/113; C12N15/63
Attorney, Agent or Firm:
SPELLBERG, Michael et al. (US)
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