Title:
OLIGOPEPTIDE HAVING BLOOD PRESSURE REDUCING EFFECT, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/197063
Kind Code:
A1
Abstract:
The present invention relates to the technical fields of rice wine lee resource utilization and blood pressure reduction, and particularly relates to an oligopeptide having a blood pressure reducing effect and a preparation method therefor and an application thereof. In order to promote comprehensive utilization of rice wine lees, the oligopeptide having the blood pressure reducing effect is developed; the rice wine lees are used as raw materials, and separated and purified to obtain the oligopeptide having the blood pressure reducing effect. The oligopeptide has an amino acid sequence as shown in SEQ ID NO: 1, has a molecular weight of 720.857 Da, is high in purity and good in activity, can be artificially synthesized, is safe and non-toxic, and is found by means of measurement of ACE inhibitory activity. The oligopeptide has a remarkable inhibition effect on angiotensin converting enzyme, can be applied to the field of blood pressure reduction, and is beneficial to resource utilization of rice wine waste.
Inventors:
CAO YONG (CN)
HE ZEQI (CN)
HE ZEQI (CN)
Application Number:
PCT/CN2021/081215
Publication Date:
October 07, 2021
Filing Date:
March 17, 2021
Export Citation:
Assignee:
UNIV SOUTH CHINA AGRICULT (CN)
International Classes:
C07K7/06; A61K38/08; A61P9/12; C07K1/16; C07K1/20
Domestic Patent References:
| WO2004082709A1 | 2004-09-30 |
Foreign References:
| CN111548387A | 2020-08-18 | |||
| CN111484545A | 2020-08-04 | |||
| CN101126105A | 2008-02-20 | |||
| EP3473640A1 | 2019-04-24 | |||
| CN109645498A | 2019-04-19 | |||
| CN101130801A | 2008-02-27 |
Other References:
YANG XUE , LI YUNLIANG , WANG YUCHENG: "Angiotensin-I-Converting Enzyme Inhibitory Activity of Rice Protein Hydrolysates and its Molecular Weight Distribution", CHINA FEED, no. 3, 5 February 2017 (2017-02-05), pages 23 - 26, XP055854827, ISSN: 1004-3314, DOI: 10.15906/j.cnki.cn11-2975/s.20170307
CHEN JIWANG, LIU SHANSHAN, YE RAN, CAI GUANGXIA, JI BO, WU YONGNING: "Angiotensin-I converting enzyme (ACE) inhibitory tripeptides from rice protein hydrolysate:Purification and characterization", JOURNAL OF FUNCTIONAL FOODS, vol. 5, no. 4, 8 August 2013 (2013-08-08), NL, pages 1684 - 1692, XP055854829, ISSN: 1756-4646, DOI: 10.1016/j.jff.2013.07.013
CHEN JIWANG, LIU SHANSHAN, YE RAN, CAI GUANGXIA, JI BO, WU YONGNING: "Angiotensin-I converting enzyme (ACE) inhibitory tripeptides from rice protein hydrolysate:Purification and characterization", JOURNAL OF FUNCTIONAL FOODS, vol. 5, no. 4, 8 August 2013 (2013-08-08), NL, pages 1684 - 1692, XP055854829, ISSN: 1756-4646, DOI: 10.1016/j.jff.2013.07.013
Attorney, Agent or Firm:
GUANGZHOU ZHENG MING INTELLECTUALPROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)
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