Title:
OLIGOSACCHARIDE COMPOUND FOR INHIBITING ENDOGENOUS COAGULATION FACTOR X-ENZYME COMPLEX, AND PREPARATION METHOD THEREFOR AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/129647
Kind Code:
A1
Abstract:
A purified oligosaccharide compound having antithrombotic activity or a mixture of a homologous compound thereof and a pharmaceutically acceptable salt thereof, a preparation method for the mixture, a pharmaceutical composition containing the mixture, and uses thereof serving as an endogenous factor X-enzyme (Xase) inhibitor in the preparation of drugs for preventing and/or treating thrombotic diseases.
Inventors:
ZHAO JINHUA (CN)
LI ZHENGUO (CN)
GAO NA (CN)
WU MINGYI (CN)
CHEN YANMING (CN)
ZHAO LONGYAN (CN)
WU YONGSHENG (CN)
LI ZI (CN)
XIAO CHUANG (CN)
ZHENG SHUNLIANG (CN)
NAN ZHIYUAN (CN)
ZHOU JIANBO (CN)
XU JIANPING (CN)
ZHOU LUTAN (CN)
GUO YAFANG (CN)
QIN HONGBO (CN)
LIU JIKAI (CN)
LI ZHENGUO (CN)
GAO NA (CN)
WU MINGYI (CN)
CHEN YANMING (CN)
ZHAO LONGYAN (CN)
WU YONGSHENG (CN)
LI ZI (CN)
XIAO CHUANG (CN)
ZHENG SHUNLIANG (CN)
NAN ZHIYUAN (CN)
ZHOU JIANBO (CN)
XU JIANPING (CN)
ZHOU LUTAN (CN)
GUO YAFANG (CN)
QIN HONGBO (CN)
LIU JIKAI (CN)
Application Number:
PCT/CN2017/070716
Publication Date:
July 19, 2018
Filing Date:
January 10, 2017
Export Citation:
Assignee:
JIUZHITANG CO LTD (CN)
MUDANJIANG YOUBO PHARMACEUTICAL CO LTD (CN)
MUDANJIANG YOUBO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07H11/00; A61K31/7024; A61K31/726; A61K31/737; A61P7/02; A61P9/10; C07H1/00; C08B37/00
Foreign References:
| CN104370980A | 2015-02-25 | |||
| CN101735336A | 2010-06-16 | |||
| CN102558389A | 2012-07-11 | |||
| CN101724086A | 2010-06-09 | |||
| CN103214591A | 2013-07-24 | |||
| CN104370980A | 2015-02-25 | |||
| CN201310099800A | 2013-03-26 | |||
| CN201110318704A | 2011-10-19 |
Other References:
GAO, NA ET AL.: "Chemical Modifications of Glycosaminoglycans and Their Derivatives for Biomedical Applications", CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS, vol. 33, no. 3, 31 March 2012 (2012-03-31), XP009515472, ISSN: 1005-1678
YOSHIDA, TETRAHEDRON LETT, vol. 33, 1992, pages 4959 - 62
MOURAO, JBIOL CHEM, vol. 271, 1996, pages 23973 - 84
THROMB HAEMOST, vol. 100, 2008, pages 420 - 8
J. BIOL. CHEM., vol. 271, 1996, pages 23973 - 84
THROMB HAEMOST, vol. 59, 1988, pages 432 - 4
THROMB HAEMOST, vol. 103, no. 5, 2010, pages 994 - 1004
THROMB HAEMOST, vol. 65, 1991, pages 369 - 73
PROC NATL ACAD SCI USA., vol. 112, no. 27, 2015, pages 8284 - 9
POMIN VH, MAR DRUGS, vol. 12, 2014, pages 232 - 54
WHISTLER RL ET AL.: "Alkaline Degradation of Polysaccharides", ADVANCES IN CARBOHYDRATE CHEMISTRY, vol. 13, 1958, pages 289 - 329
ZHAO LY ET AL., PNAS, vol. 112, 2015, pages 8284 - 8289
"Chinese Pharmacopoeia Edition", vol. IV, 2015, pages: 1142
See also references of EP 3569608A4
YOSHIDA, TETRAHEDRON LETT, vol. 33, 1992, pages 4959 - 62
MOURAO, JBIOL CHEM, vol. 271, 1996, pages 23973 - 84
THROMB HAEMOST, vol. 100, 2008, pages 420 - 8
J. BIOL. CHEM., vol. 271, 1996, pages 23973 - 84
THROMB HAEMOST, vol. 59, 1988, pages 432 - 4
THROMB HAEMOST, vol. 103, no. 5, 2010, pages 994 - 1004
THROMB HAEMOST, vol. 65, 1991, pages 369 - 73
PROC NATL ACAD SCI USA., vol. 112, no. 27, 2015, pages 8284 - 9
POMIN VH, MAR DRUGS, vol. 12, 2014, pages 232 - 54
WHISTLER RL ET AL.: "Alkaline Degradation of Polysaccharides", ADVANCES IN CARBOHYDRATE CHEMISTRY, vol. 13, 1958, pages 289 - 329
ZHAO LY ET AL., PNAS, vol. 112, 2015, pages 8284 - 8289
"Chinese Pharmacopoeia Edition", vol. IV, 2015, pages: 1142
See also references of EP 3569608A4
Attorney, Agent or Firm:
LECOME INTELLECTUAL PROPERTY AGENT LTD. (CN)
Download PDF: