Title:
ONE POT SYNTHESIS OF 4-(1,2-DIHYDRO-2-OXOBENZO[D]IMIDAZOL-3-YL)BUTANOIC ACID, A KEY INTERMEDIATE OF ZILPATEROL
Document Type and Number:
WIPO Patent Application WO/2019/207591
Kind Code:
A1
Abstract:
The present invention relates to one pot process for the preparation of 4-(1,2-dihydro-2-oxobenzo[d]imidazol-3-yl)butanoic acid of Formula- I, which is a key intermediate and its use in the preparation of Zilpaterol, which comprises condensation of methyl-4-chloro butyrate with 1-(prop-1-en-2-yl)-1H-benzo[d]imidazol-2(3H)-one in presence of a base and suitable solvent to give corresponding ester derivative, further hydrolyzation and acidification in presence of inorganic solvent to obtain Formula- I.
Inventors:
RAVI KUMAR KANNASANI (IN)
MALLIK YADAV KASA (IN)
SREENU MULA (IN)
BABU V V V (IN)
MALLIK YADAV KASA (IN)
SREENU MULA (IN)
BABU V V V (IN)
Application Number:
PCT/IN2019/050186
Publication Date:
October 31, 2019
Filing Date:
March 04, 2019
Export Citation:
Assignee:
RA CHEM PHARMA LTD (IN)
International Classes:
C07D487/06; C07C271/22
Foreign References:
| CN102603650A | 2012-07-25 | |||
| EP2535340A2 | 2012-12-19 |
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