Title:
OPHTHALMIC AND OPHTHALMOLOGICAL USE OF A COMPLEX NUTRITIVE BASE IN AN AQUEOUS MEDIUM
Document Type and Number:
WIPO Patent Application WO2004060348
Kind Code:
A3
Abstract:
The invention relates to a trophic composition in an aqueous medium comprising a complex nutritive base. The aforementioned base comprises, as a minimum, multiple amino acids, vitamins, trace elements and metallic salts, and is free of any cell growth factors, any biological extracts of animal or cell origin and any active therapeutic agents. The inventive composition is characterised in that, in addition to the complex nutritive base, it also comprises an inhibitor of the collagenases of corneal epithelium in humans or animals. The composition is further characterised in that it is formulated with the complex nutritive base in order to establish a pH of between 7.3 and 7.5 and an osmolarity of between 300 and 350 m Osm.
Inventors:
THOREL JEAN-NOEL (FR)
GATTO HUGUES (FR)
GATTO HUGUES (FR)
Application Number:
PCT/FR2003/003917
Publication Date:
September 23, 2004
Filing Date:
December 26, 2003
Export Citation:
Assignee:
THOREL JEAN-NOEL (FR)
GATTO HUGUES (FR)
GATTO HUGUES (FR)
International Classes:
A61K9/00; A61K31/401; A61K31/728; A61K45/06; A61K47/02; A61K47/18; A61P27/02; (IPC1-7): A61K9/08; A61K31/728; A61K47/02; A61K47/18; A61K31/401; A61K9/00; A61L12/14; A61P27/02; A61K47/36
Domestic Patent References:
| WO1996021421A1 | 1996-07-18 | |||
| WO2002087326A1 | 2002-11-07 | |||
| WO2002060495A1 | 2002-08-08 | |||
| WO1994015649A1 | 1994-07-21 |
Foreign References:
| US5654266A | 1997-08-05 | |||
| EP0517970A1 | 1992-12-16 | |||
| FR2425858A1 | 1979-12-14 | |||
| EP0698388A1 | 1996-02-28 | |||
| EP0468122A1 | 1992-01-29 | |||
| US5942218A | 1999-08-24 | |||
| US20020049281A1 | 2002-04-25 | |||
| US6194457B1 | 2001-02-27 |
Other References:
DATABASE WPI Section Ch Week 199018, Derwent World Patents Index; Class A96, AN 1990-135663, XP002252714
DATABASE WPI Section Ch Week 200239, Derwent World Patents Index; Class B05, AN 2002-355876, XP002252715
BERMAN M B: "COLLAGENASE INHIBITORS: RATIONALE FOR THEIR USE IN TREATING CORNEAL ULCERATION", INTERNATIONAL OPHTHALMOGY CLINICS, LITTLE, BROWN AND CO., BOSTON, US, vol. 15, no. 4, January 1975 (1975-01-01), pages 49 - 66, XP008011256, ISSN: 0020-8167
BELLON G ET AL: "EFFECTS OF PREFORMED PROLINE AND PROLINE AMINO ACID PRECURSORS INCLUDING GLUTAMINE ON COLLAGEN SYNTHESIS IN HUMAN FIBROBLAST CULTURES", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 930, no. 1, 1987, pages 39 - 47, XP002290392, ISSN: 0006-3002
VARMA S D: "SCIENTIFIC BASIS FOR MEDICAL THERAPY OF CATARACTS BY ANTIOXIDANTS", AMERICAN JOURNAL OF CLINICAL NUTRITION, BETHESDA,MD, US, vol. 53, no. 1, SUPPL, 1991, pages 335S - 345S, XP009003151, ISSN: 0002-9165
DATABASE WPI Section Ch Week 200239, Derwent World Patents Index; Class B05, AN 2002-355876, XP002252715
BERMAN M B: "COLLAGENASE INHIBITORS: RATIONALE FOR THEIR USE IN TREATING CORNEAL ULCERATION", INTERNATIONAL OPHTHALMOGY CLINICS, LITTLE, BROWN AND CO., BOSTON, US, vol. 15, no. 4, January 1975 (1975-01-01), pages 49 - 66, XP008011256, ISSN: 0020-8167
BELLON G ET AL: "EFFECTS OF PREFORMED PROLINE AND PROLINE AMINO ACID PRECURSORS INCLUDING GLUTAMINE ON COLLAGEN SYNTHESIS IN HUMAN FIBROBLAST CULTURES", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 930, no. 1, 1987, pages 39 - 47, XP002290392, ISSN: 0006-3002
VARMA S D: "SCIENTIFIC BASIS FOR MEDICAL THERAPY OF CATARACTS BY ANTIOXIDANTS", AMERICAN JOURNAL OF CLINICAL NUTRITION, BETHESDA,MD, US, vol. 53, no. 1, SUPPL, 1991, pages 335S - 345S, XP009003151, ISSN: 0002-9165
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