Title:
OPIOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/054006
Kind Code:
A1
Abstract:
Provided are an opioid receptor antagonist, which contains, as an active ingredient, one atropisomer between a pair of atropisomers of a compound represented by formula (1), said atropisomer having an opioid receptor antagonistic action, or a pharmacologically acceptable salt thereof, and a pharmaceutical composition. In formula (1), R1 represents a heteroaryl group, etc. and R2 and R3 independently represent an alkyl group, etc.
Inventors:
TAKAHASHI HIDEYO (JP)
MAKINO KOSHO (JP)
ARITA HIRONOBU (JP)
KIKUKAWA SHUNTARO (JP)
TOMIZAWA TSUKASA (JP)
FUNADA MASAHIKO (JP)
TOMIYAMA KENICHI (JP)
MAKINO KOSHO (JP)
ARITA HIRONOBU (JP)
KIKUKAWA SHUNTARO (JP)
TOMIZAWA TSUKASA (JP)
FUNADA MASAHIKO (JP)
TOMIYAMA KENICHI (JP)
Application Number:
PCT/JP2022/034681
Publication Date:
April 06, 2023
Filing Date:
September 16, 2022
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUND (JP)
NAT CENTER NEUROLOGY & PSYCHIATRY (JP)
NAT CENTER NEUROLOGY & PSYCHIATRY (JP)
International Classes:
A61K31/4468; A61K31/4525; A61P43/00; C07D405/12
Domestic Patent References:
| WO2006101245A1 | 2006-09-28 |
Foreign References:
| JPS60248670A | 1985-12-09 | |||
| US20210396706A1 | 2021-12-23 |
Other References:
SINGH P., PAI U. B.: "EFFECT OF MOLECULAR SIZE ON OPIATE RECEPTOR AFFINITY OF FENTANYL DERIVATIVES & ALPHA1-AGONIST POTENCY OF 2-AMINOTETRALINS.", INDIAN JOURNAL OF CHEMISTRY, COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (C S I R), IN, vol. 22B., no. 10., 1 October 1983 (1983-10-01), IN , pages 1076 - 1078., XP000853930, ISSN: 0019-5103
DUFFY JONATHAN, URBAS AARON, NIEMITZ MATTHIAS, LIPPA KATRICE, MARGINEAN IOAN: "Differentiation of fentanyl analogues by low-field NMR spectroscopy", ANALYTICA CHIMICA ACTA, vol. 1049, 1 February 2019 (2019-02-01), AMSTERDAM, NL , pages 161 - 169, XP093054470, ISSN: 0003-2670, DOI: 10.1016/j.aca.2018.12.014
LAMY FRANCOIS R.; DANIULAITYTE RAMINTA; BARRATT MONICA J.; LOKALA USHA; SHETH AMIT; CARLSON ROBERT G.: "Listed for sale: Analyzing data on fentanyl, fentanyl analogs and other novel synthetic opioids on one cryptomarket", DRUG AND ALCOHOL DEPENDENCE, vol. 213, 12 June 2020 (2020-06-12), IR , XP086215752, ISSN: 0376-8716, DOI: 10.1016/j.drugalcdep.2020.108115
LURIE, I.S. ; IIO, R.: "Use of multiple-reaction monitoring ratios for identifying incompletely resolved fentanyl homologs and analogs via ultra-high-pressure liquid chromatography-tandem mass spectrometry", JOURNAL OF CHROMATOGRAPHY A, vol. 1216, no. 9, 27 February 2009 (2009-02-27), AMSTERDAM, NL, pages 1515 - 1519, XP025909474, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2008.12.097
DUFFY JONATHAN, URBAS AARON, NIEMITZ MATTHIAS, LIPPA KATRICE, MARGINEAN IOAN: "Differentiation of fentanyl analogues by low-field NMR spectroscopy", ANALYTICA CHIMICA ACTA, vol. 1049, 1 February 2019 (2019-02-01), AMSTERDAM, NL , pages 161 - 169, XP093054470, ISSN: 0003-2670, DOI: 10.1016/j.aca.2018.12.014
LAMY FRANCOIS R.; DANIULAITYTE RAMINTA; BARRATT MONICA J.; LOKALA USHA; SHETH AMIT; CARLSON ROBERT G.: "Listed for sale: Analyzing data on fentanyl, fentanyl analogs and other novel synthetic opioids on one cryptomarket", DRUG AND ALCOHOL DEPENDENCE, vol. 213, 12 June 2020 (2020-06-12), IR , XP086215752, ISSN: 0376-8716, DOI: 10.1016/j.drugalcdep.2020.108115
LURIE, I.S. ; IIO, R.: "Use of multiple-reaction monitoring ratios for identifying incompletely resolved fentanyl homologs and analogs via ultra-high-pressure liquid chromatography-tandem mass spectrometry", JOURNAL OF CHROMATOGRAPHY A, vol. 1216, no. 9, 27 February 2009 (2009-02-27), AMSTERDAM, NL, pages 1515 - 1519, XP025909474, ISSN: 0021-9673, DOI: 10.1016/j.chroma.2008.12.097
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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