Title:
OPTICAL INSTRUMENT FOR MINIATURE MULTI-PHOTON MICROSCOPE, IMAGING SYSTEM AND IMAGING METHOD
Document Type and Number:
WIPO Patent Application WO/2024/104469
Kind Code:
A1
Abstract:
An optical instrument (910) for a miniature multi-photon microscope, an imaging system, and an imaging method. The optical instrument (910) is provided with a fluorescence excitation light path (400) and a fluorescence collection light path (500). The optical instrument (910) comprises: a condenser lens (310), the condenser lens (310) comprising a first lens group (311) and a second lens group (312) which are separated, the first lens group (311) being located in the fluorescence collection light path (500), the second lens group (312) being located in the fluorescence excitation light path (400) and the fluorescence collection light path (500), and the second lens group (312) being closely connected to a microscope objective lens (370). The present invention can improve the scattered fluorescence collection efficiency of miniature multi-photon microscopes, thereby increasing the imaging signal-to-noise ratio and imaging depth for observation of test specimens (380) having scattering characteristics.
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Inventors:
ZHAO CHUNZHU (CN)
WANG AIMIN (CN)
CHENG HEPING (CN)
WANG AIMIN (CN)
CHENG HEPING (CN)
Application Number:
PCT/CN2023/132378
Publication Date:
May 23, 2024
Filing Date:
November 17, 2023
Export Citation:
Assignee:
BEIJING TRANSCEND VIVOSCOPE BIO TECH CO LTD (CN)
UNIV BEIJING (CN)
UNIV BEIJING (CN)
International Classes:
G01N21/64; G01N21/01; G02B21/00
Foreign References:
| CN115575374A | 2023-01-06 | |||
| US20160274345A1 | 2016-09-22 | |||
| CN101836152A | 2010-09-15 | |||
| CN101485558A | 2009-07-22 | |||
| JP2010286566A | 2010-12-24 |
Other References:
ZHAO CHUNZHU, CHEN SHIYUAN; ZHANG LIFENG; ZHANG DONG; WU RUNLONG; HU YANHUI; ZENG FENGQINGYANG; LI YIJUN; WU DAKUN; YU FEI; ZHANG : "Miniature three-photon microscopy maximized for scattered fluorescence collection", NATURE METHODS, NATURE PUBLISHING GROUP US, NEW YORK, vol. 20, no. 4, 1 April 2023 (2023-04-01), New York, pages 617 - 622, XP093171698, ISSN: 1548-7091, DOI: 10.1038/s41592-023-01777-3
ZONG, WEIJIAN ET AL.: "Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice", NATURE METHODS, vol. 14, no. 7, 19 June 2017 (2017-06-19), pages 713 - 719, XP055783608, ISSN: 1548-7091, DOI: 10.1038/nmeth.4305
ZONG, WEIJIAN ET AL.: "Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice", NATURE METHODS, vol. 14, no. 7, 19 June 2017 (2017-06-19), pages 713 - 719, XP055783608, ISSN: 1548-7091, DOI: 10.1038/nmeth.4305
Attorney, Agent or Firm:
BEIJING BRIGHT IP AGENCY CO., LTD. (CN)
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