OPTICALLY ACTIVE 2-NITROIMIDAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE FOR PRODUCING THE SAME

Title:

OPTICALLY ACTIVE 2-NITROIMIDAZOLE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/1994/014778

Kind Code:

A1

Abstract:

A highly pure, optically active 2-nitroimidazole derivative that can be used as a concomitant drug for the radiotherapy of various tumors because it has an excellent radiosensitizing effect and a high safety. It can be produced from an inexpensive diester of tartaric acid in a high yield according to reaction scheme (I), wherein R1 and R2, which may be the same or different from each other, represent each an aliphatic or aromatic group, and X represents halogen.

Inventors:

SUZUKI TOSHIMITSU (JP)
NISHIO AZUMA (JP)

Application Number:

PCT/JP1993/001519

Publication Date:

July 07, 1994

Filing Date:

October 21, 1993

Export Citation:

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Assignee:

POLA CHEM IND INC (JP)
SUZUKI TOSHIMITSU (JP)
NISHIO AZUMA (JP)

International Classes:

C07C69/63; C07C69/78; C07D233/91; (IPC1-7): C07D233/91; C07C69/63; C07C69/76

Foreign References:

JPH03223258A

1991-10-02

Other References:

CHEMICAL ABSTRACTS, Vol. 114, No. 9 (1991), Abstract No. 82391n.
CHEMICAL ABSTRACTS, Vol. 107, No. 25 (1987), Abstract No. 237190c.

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