Title:
OPTICALLY ACTIVE PYRROLIDINE COMPOUND AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2019/065954
Kind Code:
A1
Abstract:
The present invention provides: a methyl 1-{2-[(3S, 4R)-1-[(3R, 4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl)pyrrolidin-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3-yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylate 1/2 ethane-1,2-disulfonic acid which is represented by formula (1) and is excellent in crystallinity; a method for producing the same; a production intermediate thereof; and a production method using this compound.
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Inventors:
TSURUMOTO JOJI (JP)
MOROKUMA KENJI (JP)
MOROKUMA KENJI (JP)
Application Number:
PCT/JP2018/036225
Publication Date:
April 04, 2019
Filing Date:
September 28, 2018
Export Citation:
Assignee:
MITSUBISHI TANABE PHARMA CORP (JP)
International Classes:
C07D401/14; A61K31/454; A61P43/00; C07D207/16; C07D263/26; C07D413/06; C07B61/00
Domestic Patent References:
| WO2015182723A1 | 2015-12-03 | |||
| WO2017090743A1 | 2017-06-01 | |||
| WO2015182723A1 | 2015-12-03 | |||
| WO2001047879A1 | 2001-07-05 | |||
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| WO2012118850A1 | 2012-09-07 | |||
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| WO2016021629A1 | 2016-02-11 |
Foreign References:
| JP2017105765A | 2017-06-15 | |||
| US5618949A | 1997-04-08 |
Other References:
ARENA, G. ET AL.: "Concise Synthesis of (+)-allo- Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening-Formal [3+2] Cycloaddition", ORGANIC LETTERS, vol. 15, no. 16, 2 August 2013 (2013-08-02), pages 4250 - 4253, XP055688119, ISSN: 1523-7060, DOI: 10.1021/ol4020333
MA, Z. ET AL.: "Asymmetric dipolar cycloaddition reactions: a practical, convergent synthesis of chiral pyrrolidines", TETRAHEDRON : ASYMMETRY, vol. 8, no. 6, 1997, pages 883 - 887, XP004094358, ISSN: 0957-4166, DOI: 10.1016/S0957-4166(97)00049-9
TETRAHEDRON: ASYMMETRY, vol. 8, no. 6, 1997, pages 883 - 887
TETRAHEDRON: ASYMMETRY, vol. 10, 1999, pages 2605 - 2616
ORGANIC LETTERS, vol. 8, no. 7, 2006, pages 1495 - 1498
See also references of EP 3689861A4
MA, Z. ET AL.: "Asymmetric dipolar cycloaddition reactions: a practical, convergent synthesis of chiral pyrrolidines", TETRAHEDRON : ASYMMETRY, vol. 8, no. 6, 1997, pages 883 - 887, XP004094358, ISSN: 0957-4166, DOI: 10.1016/S0957-4166(97)00049-9
TETRAHEDRON: ASYMMETRY, vol. 8, no. 6, 1997, pages 883 - 887
TETRAHEDRON: ASYMMETRY, vol. 10, 1999, pages 2605 - 2616
ORGANIC LETTERS, vol. 8, no. 7, 2006, pages 1495 - 1498
See also references of EP 3689861A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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