OPTIMIZED BACTERIAL HOST STRAINS OF METHYLOMONAS SP.16A

Title:

OPTIMIZED BACTERIAL HOST STRAINS OF METHYLOMONAS SP.16A

Document Type and Number:

WIPO Patent Application WO2005072086

Kind Code:

A3

Abstract:

Methanotrophic bacterial strains are provided that have been optimized for the production of carotenoid compounds through the down-regulation of one or more of the crtN1, ald, crtN2 andcrtN3 genes of the carotenoid biosynthetic pathway. The resulting strains lack pigmented C₃₀ carotenoid compounds, and show an increase in the production of C₄₀ carotenoids. The use of the optimized host strains for the production of the C₄₀ carotenoids canthaxanthin and astaxanthin is also described.

Inventors:

SHARPE PAMELA L (US)
CHENG QIONG (US)
BOSAK MELISSA D (US)
TAO LUAN (US)
SEDKOVA NATALIA (US)

Application Number:

PCT/US2004/040622

Publication Date:

June 08, 2006

Filing Date:

December 02, 2004

Export Citation:

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Assignee:

DU PONT (US)
SHARPE PAMELA L (US)
CHENG QIONG (US)
BOSAK MELISSA D (US)
TAO LUAN (US)
SEDKOVA NATALIA (US)

International Classes:

C12N9/00; C12N9/02; C12N9/10; C12N9/90; C12N15/52; C12P23/00; (IPC1-7): C12P5/00; C12P5/02; C12N9/00; C12N1/21; C12N1/14

Foreign References:

US6929928B2

2005-08-16

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