Title:
ORAL ADMINISTRATION OF SODIUM CHLORIDE TO PREVENT COMPLICATIONS ASSOCIATED WITH BOWEL CLEANSING WITH STIMULANT LAXATIVES
Document Type and Number:
WIPO Patent Application WO/2020/165658
Kind Code:
A3
Abstract:
A method for preventing unwanted side effects associated with the administration stimulant laxative such as bisacodyl or sodium picosulphate by orally administering sodium chloride to the patient is disclosed. Said side effects include hyponatraemia, hypokalemia, unwanted fluctuations in blood pressure, hypotension and renal failure. In certain embodiments, the sodium chloride is administered in the form of tablets during the two hours period following the administration of the stimulant laxative. This method is particularly useful in preparing patients for a colonoscopy.
Inventors:
JEEJEEBHOY KHURSHEED (CA)
Application Number:
PCT/IB2020/000205
Publication Date:
December 17, 2020
Filing Date:
February 18, 2020
Export Citation:
Assignee:
SEAFORD PHARMACEUTICALS INC (CA)
International Classes:
A61K33/14; A61K9/20; A61K31/194; A61K31/4402; A61K33/08; C01D1/02; C01D3/04; C07C59/265; C07D213/30
Domestic Patent References:
| WO2005120501A1 | 2005-12-22 | |||
| WO2003074061A1 | 2003-09-12 | |||
| WO2012079118A1 | 2012-06-21 |
Other References:
"GAVILYTE-H", RXLIST.COM, 27 December 2016 (2016-12-27), XP055771296, Retrieved from the Internet
FORDE HANNAH, O’SHEA TRIONA, DAVENPORT COLIN, SMITH DIARMUID: "Acute symptomatic hyponatraemia following sodium picosulfate/magnesium citrate as bowel preparation for colonoscopy - A case series", CASE REPORTS IN CLINICAL MEDICINE, vol. 3, no. 2, 2014, pages 101 - 104, XP055771332, DOI: 10.4236/crcm.2014.32025
COHEN ET AL.: "Hyponatraemia as a complication of colonoscopy", THE LANCET, vol. 357, 2001, pages 282 - 283, XP029609030, DOI: 10.1016/S0140-6736(00)03619-9
FORDE HANNAH, O’SHEA TRIONA, DAVENPORT COLIN, SMITH DIARMUID: "Acute symptomatic hyponatraemia following sodium picosulfate/magnesium citrate as bowel preparation for colonoscopy - A case series", CASE REPORTS IN CLINICAL MEDICINE, vol. 3, no. 2, 2014, pages 101 - 104, XP055771332, DOI: 10.4236/crcm.2014.32025
COHEN ET AL.: "Hyponatraemia as a complication of colonoscopy", THE LANCET, vol. 357, 2001, pages 282 - 283, XP029609030, DOI: 10.1016/S0140-6736(00)03619-9
Attorney, Agent or Firm:
FEENEY, Alan F. (CA)
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