Title:
ORAL GENE CARRIER AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/125031
Kind Code:
A1
Abstract:
The present invention relates to an orally-administered gene carrier, and more specifically, to an orally-administered gene carrier having cationic protamine connected to an immunoglobulin Fc region by an SMCC linker, the cationic protamine enabling the condensation of an anionic gene. The orally-administered gene carrier, according to the present invention, enables protamine, which is a protein having cationic properties, to bind to an Fc region and be condensed with a gene having anionic properties, and thus may effectively induce the in vivo expression of the gene, and when orally administered, may enable the gene to be transferred to the small intestine by protecting the gene from a degradation reaction resulting from an immune action of white blood cells and stomach acid, and may enable the half-life of the gene to be relatively long when the gene is expressed in the small intestine, and thus a potential for a long-term treatment effect has been confirmed. Thus, the gene carrier, according to the present invention, is expected to be usefully employed as an orally-administered carrier for various genes.
Inventors:
LEE YONG KYU (KR)
CHA SEUNG BIN (KR)
KANG SUNG HUN (KR)
LEE SUN HWA (KR)
CHA SEUNG BIN (KR)
KANG SUNG HUN (KR)
LEE SUN HWA (KR)
Application Number:
PCT/KR2018/016406
Publication Date:
June 27, 2019
Filing Date:
December 21, 2018
Export Citation:
Assignee:
KB BIOMED INC (KR)
International Classes:
A61K48/00; A61K9/00; A61K47/18; A61K47/42
Foreign References:
| KR20160083810A | 2016-07-12 | |||
| KR101741977B1 | 2017-05-31 |
Other References:
BAUMER, N.: "Anti body-coupled siRNA as an efficient method for in vivo mRNA knockdown", NATURE PROTOCOLS, vol. 11, 3 December 2015 (2015-12-03), pages 22 - 36, XP055238099
DATABASE NCBI 28 April 2017 (2017-04-28), "PREDICTED: Odocoileus virginianus texanus glucagon (GCG), transcript variant X2, mRNA", Database accession no. 020881848.1
DATABASE NCBI 17 April 2017 (2017-04-17), "hypothetical protein [Roseimaritima ulvae", Database accession no. 084427682.1
DATABASE NCBI 28 April 2017 (2017-04-28), "PREDICTED: Odocoileus virginianus texanus glucagon (GCG), transcript variant X2, mRNA", Database accession no. 020881848.1
DATABASE NCBI 17 April 2017 (2017-04-17), "hypothetical protein [Roseimaritima ulvae", Database accession no. 084427682.1
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
Download PDF: