Title:
ORAL HYPOGLYCEMIC PEPTIDE, FATTY ACID DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/027762
Kind Code:
A1
Abstract:
Provided are an oral hypoglycemic peptide, and a fatty acid derivative and use thereof. The sequence of the polypeptide is as shown in SEQ ID NO.1. The polypeptide or fatty acid derivative thereof may be used to prepare drugs or pharmaceutical compositions for preventing or treating diabetes, or may be used to prepare drugs or pharmaceutical compositions for lowering blood sugar. The polypeptide possesses enzymolysis resistance against a variety of proteases, may prevent failures caused by enzymolysis in the gastrointestinal tract, and is suitable as an oral hypoglycemic drug.
Inventors:
GAO XIANGDONG (CN)
TIAN HONG (CN)
LU WEICHENG (CN)
YAO WENBING (CN)
SAI WENBO (CN)
TIAN HONG (CN)
LU WEICHENG (CN)
YAO WENBING (CN)
SAI WENBO (CN)
Application Number:
PCT/CN2020/108127
Publication Date:
February 18, 2021
Filing Date:
August 10, 2020
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07K14/575; A61K38/22; A61P3/10; C07K1/107
Foreign References:
| CN110437329A | 2019-11-12 | |||
| CN103665148B | 2016-05-11 | |||
| CN109485720A | 2019-03-19 | |||
| CN106117370A | 2016-11-16 |
Other References:
BIKASH MANANDHAR, JUNG-MO AHN: "Glucagon-like Peptide-1 (GLP-1) Analogs: Recent Advances, New Possibilities, and Therapeutic Implications", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 58, no. 3, 12 February 2015 (2015-02-12), US, pages 1020 - 1037, XP055402142, ISSN: 0022-2623, DOI: 10.1021/jm500810s
YUE XUYI, KIESEWETTER DALE O., GUO JINXIA, SUN ZHONGCHAN, ZHANG XIAOXIANG, ZHU LEI, NIU GANG, MA YING, LANG LIXIN, CHEN XIAOYUAN: "Development of a New Thiol Site-Specific Prosthetic Group and Its Conjugation with [Cys 40 ]-exendin-4 for in Vivo Targeting of Insulinomas", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 24, no. 7, 17 July 2013 (2013-07-17), pages 1191 - 1200, XP055779650, ISSN: 1043-1802, DOI: 10.1021/bc400084u
PETRA ROVO, VIKTOR FARKAS, PAL STRANER, MARIA SZABO, AGNES JERMENDY, ORSOLYA HEGYI, GABOR K. TOTH, ANDRAS PERCZEL: "Rational Design of α-Helix-Stabilized Exendin-4 Analogues", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 53, no. 22, 10 June 2014 (2014-06-10), pages 3540 - 3552, XP055148240, ISSN: 00062960, DOI: 10.1021/bi500033c
YUE XUYI, KIESEWETTER DALE O., GUO JINXIA, SUN ZHONGCHAN, ZHANG XIAOXIANG, ZHU LEI, NIU GANG, MA YING, LANG LIXIN, CHEN XIAOYUAN: "Development of a New Thiol Site-Specific Prosthetic Group and Its Conjugation with [Cys 40 ]-exendin-4 for in Vivo Targeting of Insulinomas", BIOCONJUGATE CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 24, no. 7, 17 July 2013 (2013-07-17), pages 1191 - 1200, XP055779650, ISSN: 1043-1802, DOI: 10.1021/bc400084u
PETRA ROVO, VIKTOR FARKAS, PAL STRANER, MARIA SZABO, AGNES JERMENDY, ORSOLYA HEGYI, GABOR K. TOTH, ANDRAS PERCZEL: "Rational Design of α-Helix-Stabilized Exendin-4 Analogues", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 53, no. 22, 10 June 2014 (2014-06-10), pages 3540 - 3552, XP055148240, ISSN: 00062960, DOI: 10.1021/bi500033c
Attorney, Agent or Firm:
NANJING IPLEADER INTELLECTUAL PROPERTY AGENCY FIRM (CN)
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