ORAL INSULIN THERAPY - EMISPHERE TECH INC

Title:

ORAL INSULIN THERAPY

Document Type and Number:

WIPO Patent Application WO2003057170

Kind Code:

A3

Abstract:

Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence of vascular diseases associated with the repeated administration of insulin are disclosed. Also disclosed is a method of attenuating the undesirable incidence of diseases associated with chronic dosing of insulin is provided whereby the oral administration to a patient of insulin along with a suitable delivery agent that facilitates the absorption of insulin from the gastrointestinal tract of the patient in a therapeutically effective amount, for treatment of diabetes.

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Inventors:

ARBIT EHUD (US)
ABBAS RICHAT (US)
GOLDBERG MICHAEL (US)
WOOD T COOPER (US)
DINH STEVEN (US)
WONG VIVIEN (US)

Application Number:

PCT/US2003/000337

Publication Date:

December 04, 2003

Filing Date:

January 07, 2003

Export Citation:

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Assignee:

EMISPHERE TECH INC (US)
ARBIT EHUD (US)
ABBAS RICHAT (US)
GOLDBERG MICHAEL (US)
WOOD T COOPER (US)
DINH STEVEN (US)
WONG VIVIEN (US)

International Classes:

A61K9/20; G01N33/53; A61K9/48; A61K38/28; A61K47/18; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P13/12; A61P25/00; A61P43/00; G01N33/15; G01N37/00; (IPC1-7): A61K38/28

Foreign References:

US4849227A	1989-07-18
US20020003179A1	2002-01-10
US6540982B1	2003-04-01
US6399090B1	2002-06-04

Other References: