Title:
ORAL PREPARATION
Document Type and Number:
WIPO Patent Application WO/2013/178809
Kind Code:
A3
Abstract:
The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host. The invention also provides a polypeptide having methyl mercaptan oxidase activity, wherein said polypeptide is: (a) a polypeptide comprising an amino acid sequence as set out in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence having at least 50% sequence identity with the amino acid sequence of SEQ ID NO : 2; (c) a polypeptide encoded by a polynucleotide comprising the polynucleotide sequence as set out in SEQ ID NO: 1 or SEQ ID NO: 3; or (d) a fragment of a polypeptide as defined in (a), (b) or (c).
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Inventors:
EDENS LUPPO (NL)
RIJ VAN EVERT TJEERD (NL)
GROOT DE MARCO JAN LAMBERTUS (NL)
RIJ VAN EVERT TJEERD (NL)
GROOT DE MARCO JAN LAMBERTUS (NL)
Application Number:
PCT/EP2013/061316
Publication Date:
April 10, 2014
Filing Date:
May 31, 2013
Export Citation:
Assignee:
DSM IP ASSETS BV (NL)
International Classes:
A23G4/12; A61K8/66; A61Q11/02; C12N9/02
Foreign References:
| US6426112B1 | 2002-07-30 | |||
| US6074631A | 2000-06-13 | |||
| US20100055051A1 | 2010-03-04 | |||
| US20110293668A1 | 2011-12-01 |
Other References:
HYUN-HO LEE ET AL: "Purification and characterization of methyl mercaptan oxidase fromThiobacillus thioparus for mercaptan detection", BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 7, no. 6, 1 December 2002 (2002-12-01), pages 375 - 379, XP055077972, ISSN: 1226-8372, DOI: 10.1007/BF02933525
G. M. H. SUYLEN ET AL: "Methyl Mercaptan Oxidase, a Key Enzyme in the Metabolism of Methylated Sulphur Compounds by Hyphomicrobium EG", MICROBIOLOGY, vol. 133, no. 11, 1 November 1987 (1987-11-01), pages 2989 - 2997, XP055077899, ISSN: 1350-0872, DOI: 10.1099/00221287-133-11-2989
W. D. GOULD ET AL: "Purification and properties of methyl mercaptan oxidase from Thiobacillus thioparus TK-m", JOURNAL OF GENERAL MICROBIOLOGY, vol. 138, no. 1, 1 January 1992 (1992-01-01), pages 217 - 221, XP055077974, ISSN: 0022-1287, DOI: 10.1099/00221287-138-1-217
SANG-JOON KIM ET AL: "Isolation and purification of methyl mercaptan oxidase fromRhodococcus rhodochrous for mercaptan detection", BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 5, no. 6, 1 December 2000 (2000-12-01), pages 465 - 468, XP055077980, ISSN: 1226-8372, DOI: 10.1007/BF02931949
T. KANEKO ET AL: "Complete Genomic Structure of the Cultivated Rice Endophyte Azospirillum sp. B510", DNA RESEARCH, vol. 17, no. 1, 1 February 2010 (2010-02-01), pages 37 - 50, XP055077985, ISSN: 1340-2838, DOI: 10.1093/dnares/dsp026
DATABASE UniProt [online] 29 April 2008 (2008-04-29), "SubName: Full=Uncharacterized protein; Flags: Precursor;", XP002719459, retrieved from EBI accession no. UNIPROT:B1M4H1 Database accession no. B1M4H1
G. M. H. SUYLEN ET AL: "Methyl Mercaptan Oxidase, a Key Enzyme in the Metabolism of Methylated Sulphur Compounds by Hyphomicrobium EG", MICROBIOLOGY, vol. 133, no. 11, 1 November 1987 (1987-11-01), pages 2989 - 2997, XP055077899, ISSN: 1350-0872, DOI: 10.1099/00221287-133-11-2989
W. D. GOULD ET AL: "Purification and properties of methyl mercaptan oxidase from Thiobacillus thioparus TK-m", JOURNAL OF GENERAL MICROBIOLOGY, vol. 138, no. 1, 1 January 1992 (1992-01-01), pages 217 - 221, XP055077974, ISSN: 0022-1287, DOI: 10.1099/00221287-138-1-217
SANG-JOON KIM ET AL: "Isolation and purification of methyl mercaptan oxidase fromRhodococcus rhodochrous for mercaptan detection", BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, vol. 5, no. 6, 1 December 2000 (2000-12-01), pages 465 - 468, XP055077980, ISSN: 1226-8372, DOI: 10.1007/BF02931949
T. KANEKO ET AL: "Complete Genomic Structure of the Cultivated Rice Endophyte Azospirillum sp. B510", DNA RESEARCH, vol. 17, no. 1, 1 February 2010 (2010-02-01), pages 37 - 50, XP055077985, ISSN: 1340-2838, DOI: 10.1093/dnares/dsp026
DATABASE UniProt [online] 29 April 2008 (2008-04-29), "SubName: Full=Uncharacterized protein; Flags: Precursor;", XP002719459, retrieved from EBI accession no. UNIPROT:B1M4H1 Database accession no. B1M4H1
Attorney, Agent or Firm:
CHADWICK, Mark Craig (P.O. Box 130, AC Echt, NL)
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