Title:
ORALLY-BIOAVAILABLE FORMULATIONS OF FENTANYL AND CONGENERS THEREOF
Document Type and Number:
WIPO Patent Application WO2002045713
Kind Code:
A3
Abstract:
One aspect of the present invention relates to formulations of fentanyl and its congeners. A second aspect of the present invention relates to the use of the formulations of the present invention as analgesics in mammals.
Inventors:
SHAO LIMING
Application Number:
PCT/US2001/047651
Publication Date:
April 03, 2003
Filing Date:
October 26, 2001
Export Citation:
Assignee:
SEPRACOR INC (US)
International Classes:
A61K9/00; A61K31/4468; A61K47/40; A61K47/48; A61P25/04; (IPC1-7): A61K31/4468; A61K47/48; A61K47/30; A61K9/51; A61K9/127; A61P25/04
Domestic Patent References:
| WO1992002256A1 | 1992-02-20 |
Foreign References:
| US5451408A | 1995-09-19 |
Other References:
PORTENOY R K ET AL: "ORAL TRANSMUCOSAL FENTANYL CITRATE (OTFC) FOR THE TREATMENT OF BREAKTHROUGH PAIN IN CANCER PATIENTS: A CONTROLLED DOSE TITRATION STUDY", PAIN, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 2/3, no. 79, March 1999 (1999-03-01), pages 303 - 312, XP001076812, ISSN: 0304-3959
FARRAR J T ET AL: "ORAL TRANSMUCOSAL FENTANYL CITRATE: RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL FOR TREATMENT OF BREAKTHROUGH PAIN IN CANCER PATIENTS", JOURNAL OF THE NATIONAL CANCER INSTITUTE, US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, US, vol. 90, no. 8, 15 April 1998 (1998-04-15), pages 611 - 616, XP001058154, ISSN: 0027-8874
STANLEY T H ET AL: "ORAL TRANSMUCOSAL FENTANYL CITRATE (LOLLIPOP) PREMEDICATION IN HUMAN VOLUNTEERS", ANESTHESIA AND ANALGESIA, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 1, no. 69, July 1989 (1989-07-01), pages 21 - 27, XP008003100, ISSN: 0003-2999
DATABASE MEDLINE [online] 1990, MIKHAILOVA S ET AL: "[Liposomal systems--prospective drug forms. II. The creation and characterization of liposomal systems for the oral use of narcotic analgesics]", XP002208225, Database accession no. NLM1980460
FARRAR J T ET AL: "ORAL TRANSMUCOSAL FENTANYL CITRATE: RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL FOR TREATMENT OF BREAKTHROUGH PAIN IN CANCER PATIENTS", JOURNAL OF THE NATIONAL CANCER INSTITUTE, US DEPT. OF HEALTH, EDICATIONAND WELFARE, PUBLIC HEALTH, US, vol. 90, no. 8, 15 April 1998 (1998-04-15), pages 611 - 616, XP001058154, ISSN: 0027-8874
STANLEY T H ET AL: "ORAL TRANSMUCOSAL FENTANYL CITRATE (LOLLIPOP) PREMEDICATION IN HUMAN VOLUNTEERS", ANESTHESIA AND ANALGESIA, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 1, no. 69, July 1989 (1989-07-01), pages 21 - 27, XP008003100, ISSN: 0003-2999
DATABASE MEDLINE [online] 1990, MIKHAILOVA S ET AL: "[Liposomal systems--prospective drug forms. II. The creation and characterization of liposomal systems for the oral use of narcotic analgesics]", XP002208225, Database accession no. NLM1980460
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