ORALLY DELIVERABLE PHARMACEUTICAL COMPOSITION COMPRISING AN ACTIVE COMPOUND HAVING AN AMINOSULFONYL GROUP (cox-2 INHIBITOR), A POLYETHYLENE GLYCOL AND A FREE-RADICAL SCAVENGING ANTIOXIDANT

WIPO Patent Application WO2002102376

A8

An orally deliverable pharmaceutical composition is provided comprising an aminosulfonyl-comprising drug, for example a selective cyclooxygenase-2 inhibitory drug such as celecoxib, and a solvent liquid comprising a polyethylene glycol and one or more free radical-scavenging antioxidants. At least a substantial part of the drug is in dissolved form in the solvent liquid. The composition has rapid-onset properties and is useful in treatment of cyclooxygenase-2 mediated conditions and disorders.

GAO PING (US)
HUANG TIEHUA (US)
ROBINS RUSSELL H (US)
BAUER JULIANE M (US)
GUIDO JANE E (US)
BRUGGER ANDREW M (US)
KARIM AZIZ (US)
HASSAN FRED (US)
FORBES JAMES C (US)

PCT/US2002/011690

April 24, 2003

April 12, 2002

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PHARMACIA CORP (US)
GAO PING (US)
HUANG TIEHUA (US)
ROBINS RUSSELL H (US)
BAUER JULIANE M (US)
GUIDO JANE E (US)
BRUGGER ANDREW M (US)
KARIM AZIZ (US)
HASSAN FRED (US)
FORBES JAMES C (US)

A61K9/08; A61K9/48; A61K31/415; A61K31/42; A61K31/522; A61K31/635; A61K45/00; A61K45/06; A61K47/02; A61K47/04; A61K47/10; A61K47/12; A61K47/18; A61K47/22; A61K47/34; A61K47/38; A61K47/48; A61P25/06; A61P29/00; A61P43/00; C07D231/12; C07D261/08; C07D413/12; (IPC1-7): A61K31/415; A61K31/635; A61K47/48; A61K47/10; A61P29/00

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