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Title:
ORGANIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2023/178113
Kind Code:
A3
Abstract:
The invention relates to particular substituted heterocycle fused gamma-carbolines, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving the 5-HT2A receptor, the serotonin transporter (SERT), pathways involving the dopamine D1 and D2 receptor signaling system, and/or the μ-opioid receptor.

Inventors:
LI PENG (US)
DAVIS ROBERT E (US)
SNYDER GRETCHEN (US)
FIENBERG ALLEN A (US)
Application Number:
PCT/US2023/064349
Publication Date:
October 26, 2023
Filing Date:
March 14, 2023
Export Citation:
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Assignee:
INTRA CELLULAR THERAPIES INC (US)
International Classes:
C07D471/14; A61K31/485; A61K31/4985
Foreign References:
US20220048910A12022-02-17
EP1192165B12004-09-22
US20030144319A12003-07-31
Other References:
DATABASE PubChem PUBCHEM : "(4aR,9bR)-2-(furan-2-ylmethyl)-5-phenyl-3,4,4a,9b-tetrahydro-1H-pyrido[4,3-b]indole | C22H22N2O ", XP093105620, retrieved from NCBI
DATABASE PubChem PUBCHEM : "Cambridge id 5283743 | C16H16N2S ", XP093105969
DATABASE PubChem PUBCHEM : "1-(1,3,4,4a,9,9a-Hexahydropyrido[3,4-b]indol-2-yl)ethanone | C13H16N2O ", XP093105974, retrieved from NCBI
DATABASE PubChem ANONYMOUS : "Acetamide, N-(5,6,7,8-tetrahydrocarbazol-1-YL)- | C14H16N2O |", XP093105979, retrieved from NCBI
DATABASE PubChem ANONYMOUS : "3-Acetylaminocarbazole | C14H12N2O ", XP093105983, retrieved from NCBI
Attorney, Agent or Firm:
POKER, Cory (US)
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