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Title:
ORTHOESTER MIXTURE PHARMACEUTICAL EXCIPIENT, PREPARATION METHOD, AND TOPICAL SUSTAINED-RELEASE DRUG DELIVERY PREPARATION CONTAINING EXCIPIENT
Document Type and Number:
WIPO Patent Application WO/2023/103137
Kind Code:
A1
Abstract:
An orthoester mixture pharmaceutical excipient, relating to the field of pharmaceutical excipients, and mainly obtained by mixing different orthoester compounds in different proportions or by mixing orthoester compounds with biocompatible medical polymer materials in different proportions. Also disclosed are a preparation method for the pharmaceutical excipient, and a topical sustained-release drug delivery preparation containing the excipient. The beneficial effects are that: the fluidity of the orthoester mixture pharmaceutical excipient can be adjusted; the degradation rate can be controlled, and the drug release rate can be adjusted; the orthoester mixture pharmaceutical excipient can be used as a good solvent, and can dissolve small molecule and protein drugs; topical injections, creams and ointments can be prepared; good biocompatibility is achieved, metabolism is clear, and clinical translation and use are facilitated.

Inventors:
TANG RUPEI (CN)
YAN GUOQING (CN)
Application Number:
PCT/CN2022/070666
Publication Date:
June 15, 2023
Filing Date:
January 07, 2022
Export Citation:
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Assignee:
UNIV ANHUI (CN)
International Classes:
A61K9/06; A61K45/00; A61K47/10; A61K47/22; A61K47/34; C07D317/34
Foreign References:
CN103804684A2014-05-21
CN101052376A2007-10-10
CN103804339A2014-05-21
CN105358129A2016-02-24
CN103254427A2013-08-21
Other References:
WEI BING, TAO YANGYANG, WANG XIN, TANG RUPEI, WANG JUN, WANG RUI, QIU LIYING: "Surface-Eroding Poly(ortho ester amides) for Highly Efficient Oral Chemotherapy", APPLIED MATERIALS & INTERFACES, AMERICAN CHEMICAL SOCIETY, US, vol. 7, no. 19, 20 May 2015 (2015-05-20), US , pages 10436 - 10445, XP093071691, ISSN: 1944-8244, DOI: 10.1021/acsami.5b01687
Attorney, Agent or Firm:
HEFEI CITY, HAO ZHI YUN PATENTAGENCY (CN)
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