Title:
OSTEOCLAST ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2012/061907
Kind Code:
A3
Abstract:
The invention relates to medicaments and novel methods of treating metabolic bone diseases, and more particularly for treating or preventing Critical Illness Related Metabolic Bone Disease or of critical illness induced Osteopenia [ICD-10 M85.8, ICD-9 733.90, DiseasesDB 29870 or MeSH D001851] secondary to ICU Admission by sufficient autophagy inducing compound to inhibit or suppressing critical illness [MeSH Descriptor: C23.550.291.625] enhanced osteoclastogenesis or increased osteoclast differentiation. The disclosed therapeutic methods include administering of a autophagy activating compound to a mammal to: (1) treat or prevent a bone degenerative disorder; (2) slow bone deterioration; (3) restore lost bone; (4) maintain bone mass and/or bone quality or (5) inhibit bone resorption in particularly by inhibiting or reducing a process by which osteoclasts break down bone and release the minerals resulting in a transfer of calcium from bone fluid to the blood. The invention also provides methods for administering the autophagy activating compound to treat a bone disorder of hyperresorption of bone and/or enhanced activation of osteoclasts.
Inventors:
GUNST JAN (BE)
OWEN HELEN (BE)
VAN DEN BERGHE GREET (BE)
VANHOREBEEK LISE (BE)
OWEN HELEN (BE)
VAN DEN BERGHE GREET (BE)
VANHOREBEEK LISE (BE)
Application Number:
PCT/BE2011/000064
Publication Date:
August 16, 2012
Filing Date:
November 10, 2011
Export Citation:
Assignee:
UNIV LEUVEN KATH (BE)
GUNST JAN (BE)
OWEN HELEN (BE)
VAN DEN BERGHE GREET (BE)
VANHOREBEEK LISE (BE)
GUNST JAN (BE)
OWEN HELEN (BE)
VAN DEN BERGHE GREET (BE)
VANHOREBEEK LISE (BE)
International Classes:
A61K31/13; A61K31/436; A61K31/5415; A61P19/00
Other References:
JEEVANANDAM M ET AL: "Amelioration of the protein metabolic response in spermidine-supplemented trauma rats", METABOLISM, CLINICAL AND EXPERIMENTAL, W.B. SAUNDERS CO., PHILADELPHIA, PA, US, vol. 47, no. 2, 1 February 1998 (1998-02-01), pages 223 - 229, XP004538315, ISSN: 0026-0495, DOI: 10.1016/S0026-0495(98)90225-6
WEISS A J ET AL: "Pharmacological and biological therapies for metabolic bone disease in critical illness: An integrative physiology approach", CURRENT DRUG THERAPY 2010 BENTHAM SCIENCE PUBLISHERS B.V. GBR, vol. 5, no. 1, February 2010 (2010-02-01), pages 48 - 57, XP009159457, ISSN: 1574-8855
VAN DEN BERGHE GREET ET AL: "Bone turnover in prolonged critical illness: Effect of vitamin D.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 88, no. 10, October 2003 (2003-10-01), pages 4623 - 4632, XP002676254, ISSN: 0021-972X
VIA MICHAEL A ET AL: "Bone physiology and therapeutics in chronic critical illness", MOLECULAR AND INTEGRATIVE PHYSIOLOGY OF THE MUSCULOSKELETAL SYSTEM WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA SERIES : ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (ISSN 0077-8923(PRINT)), 9 November 2010 (2010-11-09), pages 85 - 94, XP002676255
WEISS A J ET AL: "Pharmacological and biological therapies for metabolic bone disease in critical illness: An integrative physiology approach", CURRENT DRUG THERAPY 2010 BENTHAM SCIENCE PUBLISHERS B.V. GBR, vol. 5, no. 1, February 2010 (2010-02-01), pages 48 - 57, XP009159457, ISSN: 1574-8855
VAN DEN BERGHE GREET ET AL: "Bone turnover in prolonged critical illness: Effect of vitamin D.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 88, no. 10, October 2003 (2003-10-01), pages 4623 - 4632, XP002676254, ISSN: 0021-972X
VIA MICHAEL A ET AL: "Bone physiology and therapeutics in chronic critical illness", MOLECULAR AND INTEGRATIVE PHYSIOLOGY OF THE MUSCULOSKELETAL SYSTEM WILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA SERIES : ANNALS OF THE NEW YORK ACADEMY OF SCIENCES (ISSN 0077-8923(PRINT)), 9 November 2010 (2010-11-09), pages 85 - 94, XP002676255
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