Title:
OXAZEPINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/204308
Kind Code:
A1
Abstract:
The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The compound has superior orexin type-2 receptor agonist activity.
Inventors:
OKADA KAZUHISA (JP)
SASAKI KOSUKE (JP)
MUTOH HIROYUKI (JP)
KIMURA KUMI (JP)
FURUYA SHIORI (JP)
SASAKI KOSUKE (JP)
MUTOH HIROYUKI (JP)
KIMURA KUMI (JP)
FURUYA SHIORI (JP)
Application Number:
PCT/JP2023/015990
Publication Date:
October 26, 2023
Filing Date:
April 21, 2023
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
International Classes:
C07D498/04; A61K31/55; A61K31/553; A61P25/02; A61P25/16; A61P25/26; A61P25/28; A61P43/00; C07D519/00
Domestic Patent References:
| WO2012061019A2 | 2012-05-10 |
Foreign References:
| JP2014522847A | 2014-09-08 | |||
| JP2009527532A | 2009-07-30 | |||
| JP2009500406A | 2009-01-08 |
Other References:
MARK TURLINGTON, MEREDITH J. NOETZEL, ASPEN CHUN, YA ZHOU, ROCCO D. GOGLIOTTI, ELIZABETH D. NGUYEN, KAREN J. GREGORY, PAIGE N. VIN: "Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu 5 ) Positive Allosteric Modulators (PAMs): Discovery of 5-((3-Fluorophenyl)ethynyl)- N -(3-methyloxetan-3-yl)picolinamide (ML254)", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 56, no. 20, 24 October 2013 (2013-10-24), pages 7976 - 7996, XP055092332, ISSN: 00222623, DOI: 10.1021/jm401028t
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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