OXAZOLIDINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Title:

OXAZOLIDINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Document Type and Number:

WIPO Patent Application WO2003072576

Kind Code:

A3

Abstract:

Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein -N-HET is, for example, formula (Ic) or (If) wherein R1 is, for example, halogen or a (1-4C)alkyl group which is substituted by one substituent selected from, for example, hydroxy, (1-4C)alkoxy, amino, cyano or azido; Q is selected from, for example, Q1, formula Q1 wherein R2 and R3 are independently hydrogen or fluoro;T is selected from a range of groups, for example, formula (TC12b) wherein m is 0, 1 or 2; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

Inventors:

GRAVESTOCK MICHAEL BARRY (US)
HALES NEIL JAMES (US)
RECK FOLKERT (US)
ZHOU FEI (US)
FLEMING PAUL ROBERT (US)
CARCANAGUE DANIEL ROBERT (US)

Application Number:

PCT/GB2003/000791

Publication Date:

December 31, 2003

Filing Date:

February 25, 2003

Export Citation:

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Assignee:

ASTRAZENECA AB (SE)
ASTRAZENECA UK LTD (GB)
GRAVESTOCK MICHAEL BARRY (US)
HALES NEIL JAMES (US)
RECK FOLKERT (US)
ZHOU FEI (US)
FLEMING PAUL ROBERT (US)
CARCANAGUE DANIEL ROBERT (US)

International Classes:

A61K31/422; A61K31/5377; C07D413/14; A61K31/661; A61P31/04; A61P43/00; C07B53/00; C07D413/04; C07F9/6558; A61K; A61P; C07D; (IPC1-7): C07D413/14; A61K31/422; A61P31/04

Domestic Patent References:

WO2001081350A1	2001-11-01
WO2001058885A1	2001-08-16
WO1995007271A1	1995-03-16
WO2002081470A1	2002-10-17

Foreign References:

EP0184170A2	1986-06-11
US6277868B1	2001-08-21

Other References:

GREGORY W A ET AL: "ANTIBACTERIALS. SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES OF 3-ARYL-2-OXOOXAZOLIDINES. I THE B GROUP", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 32, no. 8, 1 August 1989 (1989-08-01), pages 1673 - 1681, XP000573960, ISSN: 0022-2623

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