OXAZOLIDINONES AS ANTIBACTERIAL AGENTS

Title:

OXAZOLIDINONES AS ANTIBACTERIAL AGENTS

Document Type and Number:

WIPO Patent Application WO2004048350

Kind Code:

A3

Abstract:

A compound of the formula (I), or a pharmaceutically-acceptable salt, or in-vivo hydrolysable ester thereof, wherein C is selected from (D) and (E), R2a, R6a, and R3a are independently selected from for example H, CF3, Me and Et; R2b and R6b are independently selected from for example H, F, CF3, Me and Et; R1b is for example optionally substituted diazolyl, triazolyl or tetrazolyl; R4 is for example an optionally substituted 5- or 6-membered heterocyclic ring system. Methods for making compounds of the formula (I), compositions containing them and their use as antibacterial agents are also described.

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Inventors:

GRAVESTOCK MICHAEL BARRY (US)
HALES NEIL JAMES (GB)
RECK FOLKERT (US)
ZHOU FEI (US)

Application Number:

PCT/GB2003/005091

Publication Date:

October 21, 2004

Filing Date:

November 24, 2003

Export Citation:

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Assignee:

ASTRAZENECA AB (SE)
ASTRAZENECA UK LTD (GB)
GRAVESTOCK MICHAEL BARRY (US)
HALES NEIL JAMES (GB)
RECK FOLKERT (US)
ZHOU FEI (US)

International Classes:

C07D413/14; (IPC1-7): C07D413/14

Domestic Patent References:

WO2001081350A1	2001-11-01
WO2001094342A1	2001-12-13
WO2002081470A1	2002-10-17
WO2003022824A1	2003-03-20
WO2003072575A1	2003-09-04
WO2003072576A2	2003-09-04
WO2003035648A1	2003-05-01

Foreign References:

US20020115669A1

2002-08-22

Other References:

RONDSTEDT, CHRISTIAN S., JR. ET AL.: "Unsaturated sulfonic acids. V.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 77, 1955, pages 6532 - 6540, XP002290054

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