Title:
OXAZOLINONE DERIVATIVE HAVING INTRACELLULAR PHOSPHOLIPASE A2 INHIBITOR ACTIVITY
Document Type and Number:
WIPO Patent Application WO/1995/010508
Kind Code:
A1
Abstract:
A compound represented by general formula (I), and having an intracellular phospholipase A2 inhibitor activity, and a composition containing the same, wherein a and b represent each a carbon atom and the bond -- between the atoms a and b represents either a single or a double bond; X represents hydrogen, optionallysubstituted aryl, heteroaryl or aralkyl; Y represents hydrogen, optionally substituted aryl, aralkyl, carboxyl or a functional group related thereto; and Z represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, aralkyl, arylalkenyl, heteroarylalkyl, heteroarylalkenyl, aryloxyalkyl, aralkyloxyalkyl, arylcarbonylalkyl, arylsulfonylalkyl, heteroarylsulfonylalkyl, aminoalkyl, carboxyalkyl or a functional group related thereto, alkyloxycarbonyl, aralkyloxycarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl or heteroarylsulfonyl; provided the case where X, Y and Z represent simultaneously hydrogen atoms is excluded.
Inventors:
OHTANI MITSUAKI (JP)
KATO TOSHIYUKI (JP)
KATO TOSHIYUKI (JP)
Application Number:
PCT/JP1994/001716
Publication Date:
April 20, 1995
Filing Date:
October 13, 1994
Export Citation:
Assignee:
SHIONOGI & CO (JP)
OHTANI MITSUAKI (JP)
KATO TOSHIYUKI (JP)
OHTANI MITSUAKI (JP)
KATO TOSHIYUKI (JP)
International Classes:
C07D263/22; C07D263/38; C07D413/04; C07D413/06; C07D413/12; C07D413/14; C07D521/00; (IPC1-7): C07D263/38; A61K31/42; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/535; C07D413/04; C07D413/06
Foreign References:
| JPS61286375A | 1986-12-16 | |||
| JPH03500298A | 1991-01-24 | |||
| JPS53146635A | 1978-12-20 | |||
| JPS5210874B2 | 1977-03-26 | |||
| JPS5175521A | 1976-06-30 | |||
| JPS5297966A | 1977-08-17 | |||
| JPH05239078A | 1993-09-17 |
Other References:
Heterocycles, Vol. 23, No. 2, (1985), SHIBUYA, SHIROSHI, "An Enantioselective Synthesis of 1-(. Alpha.-Hydroxyalkyl)1,2,3,4-Tetrahydroisoqu inolines through Optically Active N-Oxaacyliminium Ion Intermetiates", pages 395 to 398.
Journal of Organic Chemistry, Vol. 58, No. 12, (1993), BUSACCA, CARL A. et al., "Phenethylamines via Lleck Arylation of a New Vinylamine Equivalent", pages 3299-3303.
Journal of Organic Chemistry, Vol. 49, No. 3, (1984), PADWA, ALBERT et al., "Stuidies Dealing with the Aza Claisen Rearrangement of 2-Allyloxy-Substituted Oxazoles", pages 399 to 406.
Journal of Heterocycl. Chem., Vol. 17, No. 8, (1980), GUZIEC, FRANK S. et al., "Photochemical Transformations of 4,5-Diaryl-4-Oxazolin-2-One Protecting Groups", pages 1807 to 1808.
CHEMICAL ABSTRACTS, Vol. 86, Abstract No. 189783 (1977).
CHEMICAL ABSTRACTS, Vol. 103, Abstract No. 22883 (1985).
CHEMICAL ABSTRACTS, Vol. 91, Abstract No. 176651 (1979).
CHEMICAL ABSTRACTS, Vol. 86, Abstract No. 29695 (1977).
CHEMICAL ABSTRACTS, Vol. 63, Abstract No. 11542h (1965).
See also references of EP 0675114A4
Journal of Organic Chemistry, Vol. 58, No. 12, (1993), BUSACCA, CARL A. et al., "Phenethylamines via Lleck Arylation of a New Vinylamine Equivalent", pages 3299-3303.
Journal of Organic Chemistry, Vol. 49, No. 3, (1984), PADWA, ALBERT et al., "Stuidies Dealing with the Aza Claisen Rearrangement of 2-Allyloxy-Substituted Oxazoles", pages 399 to 406.
Journal of Heterocycl. Chem., Vol. 17, No. 8, (1980), GUZIEC, FRANK S. et al., "Photochemical Transformations of 4,5-Diaryl-4-Oxazolin-2-One Protecting Groups", pages 1807 to 1808.
CHEMICAL ABSTRACTS, Vol. 86, Abstract No. 189783 (1977).
CHEMICAL ABSTRACTS, Vol. 103, Abstract No. 22883 (1985).
CHEMICAL ABSTRACTS, Vol. 91, Abstract No. 176651 (1979).
CHEMICAL ABSTRACTS, Vol. 86, Abstract No. 29695 (1977).
CHEMICAL ABSTRACTS, Vol. 63, Abstract No. 11542h (1965).
See also references of EP 0675114A4
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