Title:
OXAZOLONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2007/080882
Kind Code:
A1
Abstract:
Disclosed is a novel raw material compound which is useful for producing a novel cycloalkanecarboxamide
derivative having a cathepsin K inhibitory activity. Specifically disclosed
is an oxazolone derivative represented by the following formula (I). (I) (In
the formula (I), R1 represents a substituted or unsubstituted alkyl
group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted
alkynyl group, a substituted phenyl group, a substituted or unsubstituted naphthyl
group or a substituted or unsubstituted heterocyclic group; and ring A represents
a saturated cyclic alkylidene group having 6-7 carbon atoms.)
Inventors:
KOJI TSUNEO
KUNII HISATOMO
KOBAYASHI NOBUO
KUNII HISATOMO
KOBAYASHI NOBUO
Application Number:
PCT/JP2007/050152
Publication Date:
July 19, 2007
Filing Date:
January 10, 2007
Export Citation:
Assignee:
SEIKAGAKU KOGYO CO LTD (JP)
KOJI TSUNEO
KUNII HISATOMO
KOBAYASHI NOBUO
KOJI TSUNEO
KUNII HISATOMO
KOBAYASHI NOBUO
International Classes:
C07D263/52; C07D413/04; C07D413/06; C07D413/12; C07D413/14; C07D417/04; C07D417/10; A61K31/27; A61K31/341; A61K31/427; A61K31/428; A61K31/5375; A61P19/10; A61P43/00
Domestic Patent References:
WO1998001133A1 | 1998-01-15 | |||
WO1997001677A1 | 1997-01-16 |
Foreign References:
JPH0545883A | 1993-02-26 | |||
JPH01310324A | 1989-12-14 | |||
JPH09165360A | 1997-06-24 | |||
JP2005517640A | 2005-06-16 | |||
JP2000204071A | 2000-07-25 |
Other References:
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 206, 1995, pages 89
J. BIOL. CHEM., vol. 271, 1996, pages 12511
SCIENCE, vol. 273, 1997, pages 1236
J. BIOL. CHEM., vol. 271, 1996, pages 2126
BIOL. PHARM. BULL., vol. 19, 1996, pages 1026
NATURE STRUCTURAL BIOLOGY, vol. 4, 1997, pages 105
J. MED. CHEM., vol. 38, 1995, pages 3139
J. ENZYME INHIBITION, vol. 3, 1989, pages 13
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 153, 1988, pages 1201
J. BIOCHEM., vol. 87, 1980, pages 39
BIOCHEM., vol. 88, 1980, pages 1805
NATURE STRUCTURAL BIOLOGY, vol. 4, 1997, pages 109
PROC. NATL. ACAD. SCI. USA, vol. 94, no. 142, 1997, pages 49
J. AM. CHEM. SOC., vol. 120, no. 9, 1998, pages 114
J. MED. CHEM., vol. 41, 1988, pages 3563
BIOORG. MED. CHEM., vol. 14, 2004, pages 4333
BIOORG. MED. CHEM., vol. 14, 2004, pages 4897
J. MED. CHEM., vol. 41, 1998, pages 3563
TEZUKA ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 1106 - 1109
AIBE ET AL., BIOL. PHARM. BULL., vol. 19, 1996, pages 1026 - 1031
BARRETT, A.J.; KIRSCHKE, H., METHODS ENZYMOL., vol. 80, 1981, pages 535 - 561
See also references of EP 1975162A4
J. BIOL. CHEM., vol. 271, 1996, pages 12511
SCIENCE, vol. 273, 1997, pages 1236
J. BIOL. CHEM., vol. 271, 1996, pages 2126
BIOL. PHARM. BULL., vol. 19, 1996, pages 1026
NATURE STRUCTURAL BIOLOGY, vol. 4, 1997, pages 105
J. MED. CHEM., vol. 38, 1995, pages 3139
J. ENZYME INHIBITION, vol. 3, 1989, pages 13
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 153, 1988, pages 1201
J. BIOCHEM., vol. 87, 1980, pages 39
BIOCHEM., vol. 88, 1980, pages 1805
NATURE STRUCTURAL BIOLOGY, vol. 4, 1997, pages 109
PROC. NATL. ACAD. SCI. USA, vol. 94, no. 142, 1997, pages 49
J. AM. CHEM. SOC., vol. 120, no. 9, 1998, pages 114
J. MED. CHEM., vol. 41, 1988, pages 3563
BIOORG. MED. CHEM., vol. 14, 2004, pages 4333
BIOORG. MED. CHEM., vol. 14, 2004, pages 4897
J. MED. CHEM., vol. 41, 1998, pages 3563
TEZUKA ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 1106 - 1109
AIBE ET AL., BIOL. PHARM. BULL., vol. 19, 1996, pages 1026 - 1031
BARRETT, A.J.; KIRSCHKE, H., METHODS ENZYMOL., vol. 80, 1981, pages 535 - 561
See also references of EP 1975162A4
Attorney, Agent or Firm:
TSUKUNI, Hajime (22-12 Toranomon 1-chom, Minato-ku Tokyo 01, JP)
Download PDF:
Previous Patent: IMAGE DISPLAY DEVICE AND IMAGE DISPLAY PROGRAM
Next Patent: CYCLOALKANECARBOXAMIDE DERIVATIVE AND METHOD FOR PRODUCING SAME
Next Patent: CYCLOALKANECARBOXAMIDE DERIVATIVE AND METHOD FOR PRODUCING SAME