Title:
OXIDATION-RESISTANT SERPINS
Document Type and Number:
WIPO Patent Application WO/2021/022212
Kind Code:
A3
Abstract:
This disclosure provides SERPIN B1 polypeptides that possess neutrophil or pancreatic elastase inhibitory activity, and the elastase inhibition activity is resistant to oxidation by free radicals. The free radicals may a reactive oxygen species, or a reactive nitrogen species, or both. In some embodiments, the SERPIN B1 polypeptide comprises an amino acid substitution at residue 344 as compared to SEQ ID NO: 1. The SERPIN B1 polypeptides disclosed herein can be used to treat a patient having a disease or a genetic condition that is associated with the increased production of free radicals as compared to a normal individual or increased exposure to free radicals in environmental sources.
Inventors:
PEMBERTON PHILIP A (US)
Application Number:
PCT/US2020/044604
Publication Date:
April 01, 2021
Filing Date:
July 31, 2020
Export Citation:
Assignee:
SERPLUS TECH LLC (US)
International Classes:
C07C233/05; G01N33/50; G01N33/68
Domestic Patent References:
| WO2019067741A1 | 2019-04-04 |
Foreign References:
| US20050070477A1 | 2005-03-31 | |||
| US20180179264A1 | 2018-06-28 | |||
| US20070072798A1 | 2007-03-29 |
Other References:
PEMBERTON: "Expression and purification of recombinant human serpin B1 yields novel molecules with altered protease inhibitory activities: Functional implications", PROTEIN EXPRESSION AND PURIFICATION, vol. 170, no. Iss. 105622, 7 February 2020 (2020-02-07), pages 1 - 10, XP086082606, DOI: 10.1016/j.pep.2020.105595
Attorney, Agent or Firm:
DONALDSON, Timothy B. (US)
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