Title:
OXIDATIVE CLEAVAGE METHOD OF TROLOX AMIDE
Document Type and Number:
WIPO Patent Application WO/2024/071372
Kind Code:
A1
Abstract:
The present disclosure provides an oxidative cleavage method of a Trolox amide. More particularly, the disclosure provides a method for producing a compound of formula I, the method including a step for contacting a compound of formula II with an oxidant in a solvent, and a step for contacting the solvent with a base to promote the reaction of the compound of formula II with the oxidant. In the formulae: R1, R2, R3, R4, R5, R6, R7, R8 and R9 each independently represent a hydrogen atom, a halogen, an optionally substituted C1-6alkyl, an optionally substituted C1-6 alkoxy, or -C(=O)NRARB; and RA and RB each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl, or an optionally substituted C1-6 alkoxy.
Inventors:
USUTANI HIROTSUGU (JP)
YAMAMOTO KENJI (JP)
HIRABAYASHI JUN (JP)
YAMAMOTO KENJI (JP)
HIRABAYASHI JUN (JP)
Application Number:
PCT/JP2023/035593
Publication Date:
April 04, 2024
Filing Date:
September 29, 2023
Export Citation:
Assignee:
SUMITOMO PHARMA CO LTD (JP)
PTC THERAPEUTICS INC (US)
PTC THERAPEUTICS INC (US)
International Classes:
C07C231/12; C07C235/78; C07D311/66
Attorney, Agent or Firm:
KAMADA, Mitsunori et al. (JP)
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