Title:
OXINDOLE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/126441
Kind Code:
A1
Abstract:
Provided are an oxindole derivative and a pharmaceutical use thereof. The structure of the oxindole derivative is shown in formula (A). Experimental results show that the provided compound has significantly improved pharmacokinetic properties compared with BIBF1120, has an excellent inhibition effect on VEGFR, FGFR and PDGFR, can be used as an inhibitor of VEGFR, FGFR and/or PDGFR, as an angiogenesis inhibitor, and as a drug for preventing and/or treating various tumors including pharyngeal squamous cell carcinoma, and has wide application prospects.
Inventors:
ZHAO LIFENG (CN)
DENG JUNFENG (CN)
ZHANG LIDAN (CN)
CHU YIWEN (CN)
SONG XUEJIAO (CN)
DENG JUNFENG (CN)
ZHANG LIDAN (CN)
CHU YIWEN (CN)
SONG XUEJIAO (CN)
Application Number:
PCT/CN2020/136898
Publication Date:
June 23, 2022
Filing Date:
December 16, 2020
Export Citation:
Assignee:
UNIV CHENGDU (CN)
International Classes:
A61K31/496; C07D209/34; A61P35/00; A61P35/04
Domestic Patent References:
| WO2015009889A1 | 2015-01-22 | |||
| WO2019048974A1 | 2019-03-14 |
Foreign References:
| CN104003925A | 2014-08-27 | |||
| US20150284327A1 | 2015-10-08 | |||
| CN1391557A | 2003-01-15 |
Other References:
XU, R.; ZHAN, M.; PENG, L.; PANG, X.; YANG, J.; ZHANG, T.; JIANG, H.; ZHAO, L.; CHEN, Y.: "Design, Synthesis and biologivsl evaluation of deuterated nintedanib for improving pharmacokinetic properties", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY & SONS LTD., GB, vol. 58, no. 7, 1 June 2015 (2015-06-01), GB , pages 308 - 312, XP009191784, ISSN: 0362-4803, DOI: 10.1002/jlcr.3299
KU XIN, HEINZLMEIR STEPHANIE, HELM DOMINIC, MÉDARD GUILLAUME, KUSTER BERNHARD: "New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics", JOURNAL OF PROTEOME RESEARCH, AMERICAN CHEMICAL SOCIETY, vol. 13, no. 5, 2 May 2014 (2014-05-02), pages 2445 - 2452, XP055942922, ISSN: 1535-3893, DOI: 10.1021/pr401247t
KU XIN, HEINZLMEIR STEPHANIE, HELM DOMINIC, MÉDARD GUILLAUME, KUSTER BERNHARD: "New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics", JOURNAL OF PROTEOME RESEARCH, AMERICAN CHEMICAL SOCIETY, vol. 13, no. 5, 2 May 2014 (2014-05-02), pages 2445 - 2452, XP055942922, ISSN: 1535-3893, DOI: 10.1021/pr401247t
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY(GENERAL PARTNERSHIP) (CN)
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