OXYGENIC HETEROCYCLIC DERIVATIVES - MITSUBISHI CHEM CORP

Title:

OXYGENIC HETEROCYCLIC DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1998/004539

Kind Code:

A1

Abstract:

Oxygenic heterocyclic derivatives of general formula (I), salts thereof, and solvates or hydrates of those [wherein R?1� is formula (II) (wherein R?4� is C�11?-C�20? alkyl or the like) or the like; R?2� is C�1?-C�10? alkyl or the like; R?3� is H or formula (III) (wherein R?5� is C�1?-C�10? alkyl); and A is C�1?-C�3? alkylene or the like]. These compounds exhibit a potent inhibitory activity against cysteine proteases such as calpain.

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Inventors:

ANDO RYOICHI (JP)
MASUDA HIROKAZU (JP)
ARITOMO KEIICHI (JP)
YOSHII NARIHIKO (JP)
SAITO KEN-ICHI (JP)

Application Number:

PCT/JP1997/002598

Publication Date:

February 05, 1998

Filing Date:

July 28, 1997

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Assignee:

MITSUBISHI CHEM CORP (JP)
ANDO RYOICHI (JP)
MASUDA HIROKAZU (JP)
ARITOMO KEIICHI (JP)
YOSHII NARIHIKO (JP)
SAITO KEN ICHI (JP)

International Classes:

C07D305/08; C07D307/22; C07D309/14; (IPC1-7): C07D305/08; A61K31/335; A61K31/34; A61K31/35; C07D307/22; C07D309/14

Domestic Patent References:

WO1996025408A1

1996-08-22

Foreign References:

JPH08104685A

1996-04-23

Attorney, Agent or Firm:

Hasegawa, Koji (5-2 Marunouchi 2-chom, Chiyoda-ku Tokyo 100, JP)

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