Title:
OZONE-CONTAINING AQUEOUS SOLUTION COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2023/068366
Kind Code:
A1
Abstract:
The present invention addresses mainly the problem of providing a novel composition or pharmaceutical that targets the mitochondrial network etc. and exhibits excellent anticancer activity while having a minimal effect on normal cells. An example of the present invention is a composition comprising an aqueous solution that contains ozone and an activator (for example, a divalent iron salt, a flavin, or a nitrogen monoxide supplying agent), said composition being for inducing: fragmentation of mitochondria that have gathered uniformly in the vicinity of the cell nucleus of a cancer cell in a hypoxic state; accumulation of the fragmented mitochondria to one pole of the cell nucleus; and damage to the cell nucleus or death of the cancer cell after the accumulation.
Inventors:
SUZUKI YOSHIHIRO (JP)
SUZUKI MANAMI (JP)
INNAMI SHIZUKA (JP)
OKAJIMA HIROSHI (JP)
MATSUNAGA MOTOMU (JP)
SUZUKI MANAMI (JP)
INNAMI SHIZUKA (JP)
OKAJIMA HIROSHI (JP)
MATSUNAGA MOTOMU (JP)
Application Number:
PCT/JP2022/039317
Publication Date:
April 27, 2023
Filing Date:
October 21, 2022
Export Citation:
Assignee:
TOKYO KEIKI INC (JP)
SUZUKI YOSHIHIRO (JP)
SUZUKI YOSHIHIRO (JP)
International Classes:
A61K33/00; A61K9/08; A61K31/16; A61K31/525; A61K31/661; A61K31/6615; A61K33/26; A61K45/06; A61P1/00; A61P1/02; A61P1/04; A61P1/18; A61P11/00; A61P13/08; A61P15/00; A61P17/00; A61P19/00; A61P21/00; A61P25/00; A61P35/00; A61P35/02; A61P43/00; C01B13/10; C01B13/11
Domestic Patent References:
| WO2019107341A1 | 2019-06-06 | |||
| WO2013128905A1 | 2013-09-06 | |||
| WO2019098339A1 | 2019-05-23 |
Foreign References:
| JP2009084258A | 2009-04-23 | |||
| JP2012126649A | 2012-07-05 | |||
| JP2005103343A | 2005-04-21 |
Other References:
HESAM MOKHTARI; LEILA FARAHMAND; KIOMARS YASERIAN; NEDA JALILI; KEIVAN MAJIDZADEH‐A: "The antiproliferative effects of cold atmospheric plasma‐activated media on different cancer cell lines, the implication of ozone as a possible underlying mechanism", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 234, no. 5, 1 November 2018 (2018-11-01), US , pages 6778 - 6782, XP071328765, ISSN: 0021-9541, DOI: 10.1002/jcp.27428
COSTA DA SILVA MILENE, BRECKWOLDT MICHAEL O., VINCHI FRANCESCA, CORREIA MARGARETA P., STOJANOVIC ANA, THIELMANN CARL MAXIMILIAN, M: "Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages", FRONTIERS IN IMMUNOLOGY, vol. 8, XP093058705, DOI: 10.3389/fimmu.2017.01479
MIKKELSEN KATHLEEN, PRAKASH MONICA D., KUOL NYANBOL, NURGALI KULMIRA, STOJANOVSKA LILY, APOSTOLOPOULOS VASSO: "Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 15, pages 3763, XP093058707, DOI: 10.3390/ijms20153763
ESUMI HIROYASU, CHIN KEISHOU, KURASHIMA YUKIKO, HASEGAWA FUMIO, OGURA TSUTOMU, YONEDA MAKOTO, OZAWA TAKAYUKI: "Reversible cell cycle arrest with concomitant p21/WAF1 overexpression and mitochondrial destruction by nitric oxide", IUBMB LIFE, vol. 42, no. 4, 1 July 1997 (1997-07-01), Hoboken, USA, pages 779 - 787, XP093058710, ISSN: 1521-6543, DOI: 10.1080/15216549700203211
ADAM HUCZYŃSKI, JAN JANCZAK, MICHAŁ ANTOSZCZAK, JOANNA WIETRZYK, EWA MAJ, BOGUMIL BRZEZINSKI: "Antiproliferative activity of salinomycin and its derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 23, 1 December 2012 (2012-12-01), pages 7146 - 7150, XP055179568, ISSN: 0960894X, DOI: 10.1016/j.bmcl.2012.09.068
COSTA DA SILVA MILENE, BRECKWOLDT MICHAEL O., VINCHI FRANCESCA, CORREIA MARGARETA P., STOJANOVIC ANA, THIELMANN CARL MAXIMILIAN, M: "Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages", FRONTIERS IN IMMUNOLOGY, vol. 8, XP093058705, DOI: 10.3389/fimmu.2017.01479
MIKKELSEN KATHLEEN, PRAKASH MONICA D., KUOL NYANBOL, NURGALI KULMIRA, STOJANOVSKA LILY, APOSTOLOPOULOS VASSO: "Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 15, pages 3763, XP093058707, DOI: 10.3390/ijms20153763
ESUMI HIROYASU, CHIN KEISHOU, KURASHIMA YUKIKO, HASEGAWA FUMIO, OGURA TSUTOMU, YONEDA MAKOTO, OZAWA TAKAYUKI: "Reversible cell cycle arrest with concomitant p21/WAF1 overexpression and mitochondrial destruction by nitric oxide", IUBMB LIFE, vol. 42, no. 4, 1 July 1997 (1997-07-01), Hoboken, USA, pages 779 - 787, XP093058710, ISSN: 1521-6543, DOI: 10.1080/15216549700203211
ADAM HUCZYŃSKI, JAN JANCZAK, MICHAŁ ANTOSZCZAK, JOANNA WIETRZYK, EWA MAJ, BOGUMIL BRZEZINSKI: "Antiproliferative activity of salinomycin and its derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 23, 1 December 2012 (2012-12-01), pages 7146 - 7150, XP055179568, ISSN: 0960894X, DOI: 10.1016/j.bmcl.2012.09.068
Attorney, Agent or Firm:
SHIMIZU Naoto et al. (JP)
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