Title:
P-(SULFONYL)-ARYL AND HETEROARYLS AMINES
Document Type and Number:
WIPO Patent Application WO2001083434
Kind Code:
A3
Abstract:
This invention relates to anti-inflammatory and analgesic compounds, especially to certain p-(sulfonyl)phenyl amino derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds. The claimed compounds have prostaglandin G/H synthase inhibitor activity and are suitable for the treatment of inflammatory diseases, such as myositis, synovitis, rheumatoid arthritis, osteoarthritis, gout, ankylosing spondylitis and bursitis, for the treatment of Alzheimer's disease or of an autoimmune disease such as systemic lupus erythematosus and type I diabetes.
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Inventors:
KRAUSS NANCY ELISABETH
MIRZADEGAN TARANEH
SMITH DAVID BERNARD
WALKER KEITH ADRIAN MURRAY
MIRZADEGAN TARANEH
SMITH DAVID BERNARD
WALKER KEITH ADRIAN MURRAY
Application Number:
PCT/EP2001/004589
Publication Date:
March 28, 2002
Filing Date:
April 24, 2001
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
A61K31/137; A61K31/18; A61K31/381; A61K31/40; A61K31/44; A61K31/4402; A61P3/10; A61P19/02; A61P19/06; A61P21/00; A61P25/28; A61P29/00; A61P37/02; A61P37/06; A61P43/00; C07C317/28; C07C317/36; C07C323/36; C07C323/37; C07D207/14; C07D207/27; C07D213/36; C07D213/38; C07D213/64; C07D213/74; C07D237/12; C07D237/14; C07D277/28; C07D277/64; C07D333/20; C07D521/00; C07D207/26; (IPC1-7): C07C317/36; C07D277/28; C07D333/20; C07D207/14; C07D213/38; C07D241/16; C07D213/74; A61K31/135; A61K31/425; A61K31/38; A61K31/44
Domestic Patent References:
| WO1998001425A1 | 1998-01-15 | |||
| WO2001017982A1 | 2001-03-15 |
Foreign References:
| US3615606A | 1971-10-26 |
Other References:
C.J. DINSMORE ET AL, BIOORG. MED. CHEM. LETT., vol. 9, no. 23, 1999, pages 3301 - 3306, XP004183728
R.D. DESAI ET AL, INDIAN J. PHARM., no. 13, 1951, pages 211 - 213, XP000926589
J.H. BILLMAN ET AL, J. ORG. CHEM., vol. 27, 1962, pages 2640 - 2643, XP001015561
A.R. KATRITZKY ET AL, SYNTH. COMMUN., vol. 23, no. 3, 1993, pages 405 - 417, XP000926588
R.D. DESAI ET AL, INDIAN J. PHARM., no. 13, 1951, pages 211 - 213, XP000926589
J.H. BILLMAN ET AL, J. ORG. CHEM., vol. 27, 1962, pages 2640 - 2643, XP001015561
A.R. KATRITZKY ET AL, SYNTH. COMMUN., vol. 23, no. 3, 1993, pages 405 - 417, XP000926588
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