Title:
P2X4 RECEPTOR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2013/105608
Kind Code:
A1
Abstract:
The present invention relates to a diazepine derivative represented by general formula (I) (In the formula: R1 and R2 are a hydrogen atom, etc. or R1 and R2 together with a benzene ring to which they are attached are a naphthalene ring, etc.; R3 and R4 are a hydrogen atom, etc.; R5 is a hydrogen atom, etc.; R6 and R7 are a hydrogen atom, etc.; X is C, CH or N and Y is N, NH or C (=O), provided that when X is N, Y is not N or NH and when X is C or CH, Y is not C (=O); Z is an oxygen atom or a sulfur atom; A is a benzene ring, etc.; B is NHC (=O), etc.; D is an atomic bonding, etc.; E is an atomic bonding, etc.; G is benzene which may by substituted, etc.; and m is an integer of 0 to 5.) or a pharmaceutically acceptable salt thereof, and a P2X4 receptor antagonist.
Inventors:
USHIODA MASATOSHI (JP)
KOBAYASHI KUNIO (JP)
SAITO DAISUKE (JP)
SAKUMA SHOGO (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
KOBAYASHI KUNIO (JP)
SAITO DAISUKE (JP)
SAKUMA SHOGO (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
Application Number:
PCT/JP2013/050320
Publication Date:
July 18, 2013
Filing Date:
January 10, 2013
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
International Classes:
C07D243/12; A61K31/551; A61P25/04; A61P43/00; C07D401/12; C07D403/12; C07D405/12; C07D409/12
Domestic Patent References:
| WO2010093061A1 | 2010-08-19 | |||
| WO2010090300A1 | 2010-08-12 | |||
| WO2008023847A1 | 2008-02-28 | |||
| WO2012008478A1 | 2012-01-19 | |||
| WO2012011549A1 | 2012-01-26 | |||
| WO2004085440A1 | 2004-10-07 | |||
| WO2008023847A1 | 2008-02-28 | |||
| WO2010093061A1 | 2010-08-19 | |||
| WO2010090300A1 | 2010-08-12 | |||
| WO2004041258A2 | 2004-05-21 | |||
| WO2007109182A2 | 2007-09-27 |
Foreign References:
| JP2006521308A | 2006-09-21 | |||
| JP2005516918A | 2005-06-09 | |||
| JPH02304437A | 1990-12-18 | |||
| JP2006509832A | 2006-03-23 | |||
| US20050074819A1 | 2005-04-07 | |||
| JPH02304437A | 1990-12-18 |
Other References:
BUELL ET AL., EMBO J., vol. 15, 1996, pages 55 - 62
SEGUELA ET AL., J. NEUROSCI., vol. 16, 1996, pages 448 - 455
BO ET AL., FEBS LETT., vol. 375, 1995, pages 129 - 133
SOTO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 3684 - 3788
WANG ET AL., BIOCHEM. RES. COMMUN., vol. 220, 1996, pages 196 - 202
M. TSUDA ET AL., NATURE, vol. 424, 2003, pages 778 - 783
JEFFREY A.M. COULL ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
"The 49th Convention of The Japanese Society for Neurochemistry", PROGRAM LECTURE ABSTRACT P3-N-114, 2006
CHAPLAN SR; BACH FW; POGREL JW; CHUNG JM; YAKSH TL.: "Quantitative assessment of tactile allodynia in the rat paw", J. NEUROSCI. METHODS, vol. 53, 1994, pages 55 - 63, XP024352718, DOI: doi:10.1016/0165-0270(94)90144-9
See also references of EP 2803662A4
SEGUELA ET AL., J. NEUROSCI., vol. 16, 1996, pages 448 - 455
BO ET AL., FEBS LETT., vol. 375, 1995, pages 129 - 133
SOTO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 3684 - 3788
WANG ET AL., BIOCHEM. RES. COMMUN., vol. 220, 1996, pages 196 - 202
M. TSUDA ET AL., NATURE, vol. 424, 2003, pages 778 - 783
JEFFREY A.M. COULL ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
"The 49th Convention of The Japanese Society for Neurochemistry", PROGRAM LECTURE ABSTRACT P3-N-114, 2006
CHAPLAN SR; BACH FW; POGREL JW; CHUNG JM; YAKSH TL.: "Quantitative assessment of tactile allodynia in the rat paw", J. NEUROSCI. METHODS, vol. 53, 1994, pages 55 - 63, XP024352718, DOI: doi:10.1016/0165-0270(94)90144-9
See also references of EP 2803662A4
Attorney, Agent or Firm:
Chigusa, Shinichi (JP)
1000 Shin-ichi Kusa (JP)
1000 Shin-ichi Kusa (JP)
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