Title:
P38 MAPK/MK2 PATHWAY REGULATOR, COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/125707
Kind Code:
A1
Abstract:
Disclosed in the present disclosure are a compound as shown in formula I, a racemate, a stereoisomer, a tautomer, an isotope label, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, and a composition thereof, a preparation method therefor and the use thereof. The compound has a good regulation effect on a p38 MAPK/MK2 pathway, good selectivity, and good pharmacokinetic properties. Furthermore, the compound can be used for treating diseases mediated by a p38 kinase inhibitor, and for preparing a medicament for such conditions or diseases.
Inventors:
LUAN LINBO (CN)
YAO YUANSHAN (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
YAO YUANSHAN (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2022/142965
Publication Date:
July 06, 2023
Filing Date:
December 28, 2022
Export Citation:
Assignee:
SHANGHAI MEIYUE BIOTECH DEV CO LTD (CN)
International Classes:
C07D401/14; A61K31/506; A61K31/5377; A61P1/00; A61P1/04; A61P3/00; A61P9/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P25/00; A61P25/28; A61P29/00; A61P35/00; A61P37/06; A61P37/08; C07D471/10; C07D487/04; C07D487/10; C07D491/107
Domestic Patent References:
| WO2022212489A1 | 2022-10-06 | |||
| WO2021022186A1 | 2021-02-04 |
Foreign References:
| CN115636814A | 2023-01-24 | |||
| CN103391718A | 2013-11-13 | |||
| CN105263326A | 2016-01-20 | |||
| CN105163738A | 2015-12-16 | |||
| CN101277962A | 2008-10-01 |
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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