Title:
PERNASAL PREPARATION COMPRISING threo-3-(3,4-DIHYDROXYPHENYL)SERINE
Document Type and Number:
WIPO Patent Application WO/1994/025017
Kind Code:
A1
Abstract:
A pernasal preparation is produced in liquid form (in an amount of 10 ml) by adding 200 mg of L-threo-3-(3,4-dihydroxyphenyl)serine, 200 mg of disodium glycyrrhetic acid 3-0-monohemiphthalate and 100 mg of sodium ascorbate to a tris hydrochloride solution to adjust the pH to 4.5. This preparation is lowly irritant for the nasal mucosa and suitable for administering a clinically effective amount of L-threo-3-(3,4-dihydroxyphenyl)serine through the nasal mucosa.
Inventors:
ANDO YUKIO (JP)
ANDO MASAYUKI (JP)
TANAKA YOSHIYA (JP)
GOTO TOSHIOMI (JP)
ANDO MASAYUKI (JP)
TANAKA YOSHIYA (JP)
GOTO TOSHIOMI (JP)
Application Number:
PCT/JP1994/000694
Publication Date:
November 10, 1994
Filing Date:
April 26, 1994
Export Citation:
Assignee:
SUMITOMO PHARMA (JP)
ANDO YUKIO (JP)
ANDO MASAYUKI (JP)
TANAKA YOSHIYA (JP)
GOTO TOSHIOMI (JP)
ANDO YUKIO (JP)
ANDO MASAYUKI (JP)
TANAKA YOSHIYA (JP)
GOTO TOSHIOMI (JP)
International Classes:
A61K9/08; A61K9/00; A61K31/195; A61P9/00; A61P25/00; (IPC1-7): A61K31/195; A61K9/08; A61K47/12; A61K47/24
Foreign References:
| JPH02111A | 1990-01-05 | |||
| JPS58121258A | 1983-07-19 | |||
| JPH01233230A | 1989-09-19 | |||
| JPS59130820A | 1984-07-27 |
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