PROCESS FOR OBTAINING 17 beta -(N-TERC-BUTYLCARBAMOYL)-3-ONE-4-AZA-STEROIDS

Title:

PROCESS FOR OBTAINING 17 beta -(N-TERC-BUTYLCARBAMOYL)-3-ONE-4-AZA-STEROIDS

Document Type and Number:

WIPO Patent Application WO2001002422

Kind Code:

A9

Abstract:

17 beta -(N-terc-butylcarbamoyl)-3-one-4-aza-steroids (I) can be obtained by a process which comprises the reaction of 17 beta -(alcoxycarbonyl)-3-one-4-aza-steroid with terc-butylamide of lithium in an organic solvent. Some compounds of formula (I), for example finasteride, are useful as inhibitors of 5- alpha -reductase and can be used in the treatment of benign prostatic hyperplasia and alopecia.

Inventors:

SILVA GUISASOLA LUIS OCTAVIO (ES)
BLANCO FERNANDEZ CRISTINA (ES)
LORENTE BONDE-LARSEN ANTONIO (ES)
MARTIN JUAREZ JORGE (ES)

Application Number:

PCT/ES2000/000239

Publication Date:

April 05, 2001

Filing Date:

July 05, 2000

Export Citation:

Click for automatic bibliography generation Help

Assignee:

RAGA CONSULTORES S L (ES)
SILVA GUISASOLA LUIS OCTAVIO (ES)
BLANCO FERNANDEZ CRISTINA (ES)
LORENTE BONDE LARSEN ANTONIO (ES)
MARTIN JUAREZ JORGE (ES)

International Classes:

A61P17/14; A61P43/00; C07J73/00; (IPC1-7): C07J73/00; A61K31/58

Download PDF:

View/Download PDF PDF Help

Previous Patent: A METHOD FOR PURIFYING PHYTOSTEROL CONCENTRATES USING A PRESSURIZED FLUID (CARBON DIOXIDE)

Next Patent: 2'-GUANIDINYL-SUBSTITUTED OLIGONUCLEOTIDES AND GENE EXPRESSION MODULATION THEREWITH