Title:
PROCESS FOR PRODUCING $g(g)-GLUTAMYLCYSTEINE
Document Type and Number:
WIPO Patent Application WO/2001/090310
Kind Code:
A1
Abstract:
A yeast extract is produced by using a Saccharomyces cerevisiae strain which can contain 1% by weight or more of $g(g)-glutamylcysteine in the logarithmic growth phase and contains from 0.004 to 0.1% by weight of glutathione when cultured in a medium wherein a glutathione synthase-lacking strain of S. cerevisiae grows more slowly than wild-type S. cerevisiae (for example, an S. cerevisiae strain lacking the C-terminal domain following Arg at the 370-position of glutathione synthase encoded by glutathione synthase gene at the chromosome).
More Like This:
Inventors:
NISHIUCHI HIROAKI (JP)
SANO KOUICHIRO (JP)
SUGIMOTO REIKO (JP)
UEDA YOICHI (JP)
SANO KOUICHIRO (JP)
SUGIMOTO REIKO (JP)
UEDA YOICHI (JP)
Application Number:
PCT/JP2001/004366
Publication Date:
November 29, 2001
Filing Date:
May 24, 2001
Export Citation:
Assignee:
AJINOMOTO KK (JP)
NISHIUCHI HIROAKI (JP)
SANO KOUICHIRO (JP)
SUGIMOTO REIKO (JP)
UEDA YOICHI (JP)
NISHIUCHI HIROAKI (JP)
SANO KOUICHIRO (JP)
SUGIMOTO REIKO (JP)
UEDA YOICHI (JP)
International Classes:
A23L1/28; A23L1/30; C12N1/16; C12N1/19; C12N9/00; C12N15/52; C12P1/02; C12P13/04; (IPC1-7): C12N1/16; C12N1/19; C12N15/52; C12P1/02
Foreign References:
| JPH0670752A | 1994-03-15 |
Other References:
INOUE,YOSHIHARU ET AL.: "Molecular identification of glutathione synthetase (GSH2) gene from saccharomyces cerevisiae", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1395, no. 3, 11 February 1998 (1998-02-11), pages 315 - 320, XP002945457
YASUYUKI OOMURA ET AL.: "Glutathione kouseisan koubo no ikushu", BIOSCIENCE TO INDUSTRY, vol. 50, no. 10, 1 October 1992 (1992-10-01), pages 989 - 994, XP002945458
OMURA,FUMIHIKO ET AL.: "Single point mutations in met 4p impair the transcriptional repression of MET genes in saccharomyces cerevisiae", FEBS LETTERS, vol. 387, no. 2-3, June 1996 (1996-06-01), pages 179 - 183, XP002945459
GRANT,CHRIS M. ET AL.: "Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine", MOLECULAR BIOLOGY OF THE CELL, vol. 8, no. 9, September 1997 (1997-09-01), pages 1699 - 1707, XP002945460
SUGIYAMA,KEI-ICHI ET AL.: "The Yap1p-dependent induction of glutathione synthesis in heat shock response of saccharomyces cerevisiae", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 20, 19 May 2000 (2000-05-19), pages 15535 - 15540, XP002945461
YASUYUKI OOMURA ET AL.: "Glutathione kouseisan koubo no ikushu", BIOSCIENCE TO INDUSTRY, vol. 50, no. 10, 1 October 1992 (1992-10-01), pages 989 - 994, XP002945458
OMURA,FUMIHIKO ET AL.: "Single point mutations in met 4p impair the transcriptional repression of MET genes in saccharomyces cerevisiae", FEBS LETTERS, vol. 387, no. 2-3, June 1996 (1996-06-01), pages 179 - 183, XP002945459
GRANT,CHRIS M. ET AL.: "Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine", MOLECULAR BIOLOGY OF THE CELL, vol. 8, no. 9, September 1997 (1997-09-01), pages 1699 - 1707, XP002945460
SUGIYAMA,KEI-ICHI ET AL.: "The Yap1p-dependent induction of glutathione synthesis in heat shock response of saccharomyces cerevisiae", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 20, 19 May 2000 (2000-05-19), pages 15535 - 15540, XP002945461
Attorney, Agent or Firm:
Toyama, Tsutomu (Higashi Nihonbashi 3-chome Chuo-ku, Tokyo, JP)
Download PDF:
Previous Patent: PEPTIDES THAT STIMULATE MYCOBACTERIAL GROWTH
Next Patent: AMMONIA-OXIDIZING BACTERIA
Next Patent: AMMONIA-OXIDIZING BACTERIA